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5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.
J Med Chem. 2023 Aug 10;66(15):10849-10865. doi: 10.1021/acs.jmedchem.3c01114. Epub 2023 Aug 1.
J Med Chem. 2023.
PMID: 37527664
Free PMC article.
Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5.
Tumber A, Salah E, Brewitz L, Corner TP, Schofield CJ.
Tumber A, et al. Among authors: corner tp.
RSC Chem Biol. 2023 Mar 20;4(6):399-413. doi: 10.1039/d2cb00249c. eCollection 2023 Jun 7.
RSC Chem Biol. 2023.
PMID: 37292060
Free PMC article.
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Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α.
Corner TP, Teo RZR, Wu Y, Salah E, Nakashima Y, Fiorini G, Tumber A, Brasnett A, Holt-Martyn JP, Figg WD Jr, Zhang X, Brewitz L, Schofield CJ.
Corner TP, et al.
Chem Sci. 2023 Oct 27;14(43):12098-12120. doi: 10.1039/d3sc04253g. eCollection 2023 Nov 8.
Chem Sci. 2023.
PMID: 37969593
Free PMC article.
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Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling.
Šimelis K, Saraç H, Salah E, Nishio K, McAllister TE, Corner TP, Tumber A, Belle R, Schofield CJ, Suga H, Kawamura A.
Šimelis K, et al. Among authors: corner tp.
Bioorg Med Chem. 2024 Feb 1;99:117597. doi: 10.1016/j.bmc.2024.117597. Epub 2024 Jan 12.
Bioorg Med Chem. 2024.
PMID: 38262305
Free article.
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The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia.
Lawson H, Holt-Martyn JP, Dembitz V, Kabayama Y, Wang LM, Bellani A, Atwal S, Saffoon N, Durko J, van de Lagemaat LN, De Pace AL, Tumber A, Corner T, Salah E, Arndt C, Brewitz L, Bowen M, Dubusse L, George D, Allen L, Guitart AV, Fung TK, So CWE, Schwaller J, Gallipoli P, O'Carroll D, Schofield CJ, Kranc KR.
Lawson H, et al.
Nat Cancer. 2024 Apr 18. doi: 10.1038/s43018-024-00761-w. Online ahead of print.
Nat Cancer. 2024.
PMID: 38637657
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