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ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
J Clin Invest. 2018 Oct 1;128(10):4485-4500. doi: 10.1172/JCI99768. Epub 2018 Jul 19.
J Clin Invest. 2018.
PMID: 30024858
Free PMC article.
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Sperandio D, Aktoudianakis V, Babaoglu K, Chen X, Elbel K, Chin G, Corkey B, Du J, Jiang B, Kobayashi T, Mackman R, Martinez R, Yang H, Zablocki J, Kusam S, Jordan K, Webb H, Bates JG, Lad L, Mish M, Niedziela-Majka A, Metobo S, Sapre A, Hung M, Jin D, Fung W, Kan E, Eisenberg G, Larson N, Newby ZER, Lansdon E, Tay C, Neve RM, Shevick SL, Breckenridge DG.
Sperandio D, et al.
Bioorg Med Chem. 2019 Feb 1;27(3):457-469. doi: 10.1016/j.bmc.2018.11.020. Epub 2018 Nov 15.
Bioorg Med Chem. 2019.
PMID: 30606676
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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.
Zablocki JA, Elzein E, Li X, Koltun DO, Parkhill EQ, Kobayashi T, Martinez R, Corkey B, Jiang H, Perry T, Kalla R, Notte GT, Saunders O, Graupe M, Lu Y, Venkataramani C, Guerrero J, Perry J, Osier M, Strickley R, Liu G, Wang WQ, Hu L, Li XJ, El-Bizri N, Hirakawa R, Kahlig K, Xie C, Li CH, Dhalla AK, Rajamani S, Mollova N, Soohoo D, Lepist EI, Murray B, Rhodes G, Belardinelli L, Desai MC.
Zablocki JA, et al.
J Med Chem. 2016 Oct 13;59(19):9005-9017. doi: 10.1021/acs.jmedchem.6b00939. Epub 2016 Oct 3.
J Med Chem. 2016.
PMID: 27690427
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Enantioselective cyclization of enamide-ynes and application to the synthesis of the kopsifoline core.
Corkey BK, Heller ST, Wang YM, Toste FD.
Corkey BK, et al.
Tetrahedron. 2013 Jul 8;69(27-28):5640-5646. doi: 10.1016/j.tet.2013.02.091.
Tetrahedron. 2013.
PMID: 23772095
Free PMC article.
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Gold(I)-catalyzed cyclizations of silyl enol ethers: application to the synthesis of (+)-lycopladine A.
Staben ST, Kennedy-Smith JJ, Huang D, Corkey BK, Lalonde RL, Toste FD.
Staben ST, et al. Among authors: corkey bk.
Angew Chem Int Ed Engl. 2006 Sep 11;45(36):5991-4. doi: 10.1002/anie.200602035.
Angew Chem Int Ed Engl. 2006.
PMID: 16888820
No abstract available.
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Palladium-catalyzed enantioselective cyclization of silyloxy-1,6-enynes.
Corkey BK, Toste FD.
Corkey BK, et al.
J Am Chem Soc. 2007 Mar 14;129(10):2764-5. doi: 10.1021/ja068723r. Epub 2007 Feb 17.
J Am Chem Soc. 2007.
PMID: 17305344
No abstract available.
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Enantioselective cyclizations of silyloxyenynes catalyzed by cationic metal phosphine complexes.
Brazeau JF, Zhang S, Colomer I, Corkey BK, Toste FD.
Brazeau JF, et al. Among authors: corkey bk.
J Am Chem Soc. 2012 Feb 8;134(5):2742-9. doi: 10.1021/ja210388g. Epub 2012 Jan 31.
J Am Chem Soc. 2012.
PMID: 22296571
Free PMC article.
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Catalytic enantioselective Conia-ene reaction.
Corkey BK, Toste FD.
Corkey BK, et al.
J Am Chem Soc. 2005 Dec 14;127(49):17168-9. doi: 10.1021/ja055059q.
J Am Chem Soc. 2005.
PMID: 16332048
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