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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra HJ, Bakker OB, Deelen P, Shireby G, Hannon E, Moisse M, Baird D, Restuadi R, Dolzhenko E, Dekker AM, Gawor K, Westeneng HJ, Tazelaar GHP, van Eijk KR, Kooyman M, Byrne RP, Doherty M, Heverin M, Al Khleifat A, Iacoangeli A, Shatunov A, Ticozzi N, Cooper-Knock J, Smith BN, Gromicho M, Chandran S, Pal S, Morrison KE, Shaw PJ, Hardy J, Orrell RW, Sendtner M, Meyer T, Başak N, van der Kooi AJ, Ratti A, Fogh I, Gellera C, Lauria G, Corti S, Cereda C, Sproviero D, D'Alfonso S, Sorarù G, Siciliano G, Filosto M, Padovani A, Chiò A, Calvo A, Moglia C, Brunetti M, Canosa A, Grassano M, Beghi E, Pupillo E, Logroscino G, Nefussy B, Osmanovic A, Nordin A, Lerner Y, Zabari M, Gotkine M, Baloh RH, Bell S, Vourc'h P, Corcia P, Couratier P, Millecamps S, Meininger V, Salachas F, Mora Pardina JS, Assialioui A, Rojas-García R, Dion PA, Ross JP, Ludolph AC, Weishaupt JH, Brenner D, Freischmidt A, Bensimon G, Brice A, Durr A, Payan CAM, Saker-Delye S, Wood NW, Topp S, Rademakers R, Tittmann L, Lieb W, Franke A, Ripke S, Braun A, Kraft J, Whiteman DC, Olsen CM, Uitterlinden AG, Hofman A, Rietschel … See abstract for full author list ➔ van Rheenen W, et al. Among authors: corcia p. Nat Genet. 2021 Dec;53(12):1636-1648. doi: 10.1038/s41588-021-00973-1. Epub 2021 Dec 6. Nat Genet. 2021. PMID: 34873335 Free PMC article.
Causes of death in a post-mortem series of ALS patients.
Corcia P, Pradat PF, Salachas F, Bruneteau G, Forestier Nl, Seilhean D, Hauw JJ, Meininger V. Corcia P, et al. Amyotroph Lateral Scler. 2008;9(1):59-62. doi: 10.1080/17482960701656940. Amyotroph Lateral Scler. 2008. PMID: 17924236
Dyslipidemia is a protective factor in amyotrophic lateral sclerosis.
Dupuis L, Corcia P, Fergani A, Gonzalez De Aguilar JL, Bonnefont-Rousselot D, Bittar R, Seilhean D, Hauw JJ, Lacomblez L, Loeffler JP, Meininger V. Dupuis L, et al. Among authors: corcia p. Neurology. 2008 Mar 25;70(13):1004-9. doi: 10.1212/01.wnl.0000285080.70324.27. Epub 2008 Jan 16. Neurology. 2008. PMID: 18199832
[Genetics of motor neuron disorders].
Corcia P, Praline J, Vourc'h P, Andres C. Corcia P, et al. Rev Neurol (Paris). 2008 Feb;164(2):115-30. doi: 10.1016/j.neurol.2007.10.002. Epub 2008 Feb 20. Rev Neurol (Paris). 2008. PMID: 18358870 Review. French.
Management of amyotrophic lateral sclerosis.
Corcia P, Meininger V. Corcia P, et al. Drugs. 2008;68(8):1037-48. doi: 10.2165/00003495-200868080-00003. Drugs. 2008. PMID: 18484797 Review.
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, Sapp PC, van Vught PW, McKenna-Yasek DM, Blauw HM, Cho TJ, Polak M, Shi L, Wills AM, Broom WJ, Ticozzi N, Silani V, Ozoguz A, Rodriguez-Leyva I, Veldink JH, Ivinson AJ, Saris CG, Hosler BA, Barnes-Nessa A, Couture N, Wokke JH, Kwiatkowski TJ Jr, Ophoff RA, Cronin S, Hardiman O, Diekstra FP, Leigh PN, Shaw CE, Simpson CL, Hansen VK, Powell JF, Corcia P, Salachas F, Heath S, Galan P, Georges F, Horvitz HR, Lathrop M, Purcell S, Al-Chalabi A, Brown RH Jr. Landers JE, et al. Among authors: corcia p. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9004-9. doi: 10.1073/pnas.0812937106. Epub 2009 May 18. Proc Natl Acad Sci U S A. 2009. PMID: 19451621 Free PMC article.
CADASIL and ALS: a link?
Praline J, Limousin N, Vourc'h P, Pallix M, Debiais S, Guennoc AM, Andres CR, Corcia P. Praline J, et al. Among authors: corcia p. Amyotroph Lateral Scler. 2010 Aug;11(4):399-401. doi: 10.1080/17482960903033153. Amyotroph Lateral Scler. 2010. PMID: 19488902
315 results