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Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic E. coli adhesin.
Berndsen ZT, Akhtar M, Thapa M, Vickers T, Schmitz A, Torres JL, Baboo S, Kumar P, Khatoom N, Sheikh A, Hamrick M, Diedrich JK, Martinez-Bartolome S, Garrett PT, Yates JR, Turner JS, Laird RM, Poly F, Porter CK, Copps J, Ellebedy AH, Ward AB, Fleckenstein JM. Berndsen ZT, et al. Among authors: copps j. bioRxiv [Preprint]. 2024 May 8:2024.05.08.593125. doi: 10.1101/2024.05.08.593125. bioRxiv. 2024. PMID: 38766097 Free PMC article. Preprint.
Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection.
Martin GM, Torres JL, Pholcharee T, Oyen D, Flores-Garcia Y, Gibson G, Moskovitz R, Beutler N, Jung DD, Copps J, Lee WH, Gonzalez-Paez G, Emerling D, MacGill RS, Locke E, King CR, Zavala F, Wilson IA, Ward AB. Martin GM, et al. Among authors: copps j. Nat Commun. 2023 Jul 28;14(1):4546. doi: 10.1038/s41467-023-40151-x. Nat Commun. 2023. PMID: 37507365 Free PMC article.
Evolving spike-protein N-glycosylation in SARS-CoV-2 variants.
Baboo S, Diedrich JK, Torres JL, Copps J, Singh B, Garrett PT, Ward AB, Paulson JC, Yates JR 3rd. Baboo S, et al. Among authors: copps j. bioRxiv [Preprint]. 2023 Dec 18:2023.05.08.539897. doi: 10.1101/2023.05.08.539897. bioRxiv. 2023. PMID: 37214937 Free PMC article. Preprint.
Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimmers as HIV-1 vaccine candidates.
Zhang YN, Paynter J, Antanasijevic A, Allen JD, Eldad M, Lee YZ, Copps J, Newby ML, He L, Chavez D, Frost P, Goodroe A, Dutton J, Lanford R, Chen C, Wilson IA, Crispin M, Ward AB, Zhu J. Zhang YN, et al. Among authors: copps j. Nat Commun. 2023 Apr 8;14(1):1985. doi: 10.1038/s41467-023-37742-z. Nat Commun. 2023. PMID: 37031217 Free PMC article.
A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike.
Claireaux M, Caniels TG, de Gast M, Han J, Guerra D, Kerster G, van Schaik BDC, Jongejan A, Schriek AI, Grobben M, Brouwer PJM, van der Straten K, Aldon Y, Capella-Pujol J, Snitselaar JL, Olijhoek W, Aartse A, Brinkkemper M, Bontjer I, Burger JA, Poniman M, Bijl TPL, Torres JL, Copps J, Martin IC, de Taeye SW, de Bree GJ, Ward AB, Sliepen K, van Kampen AHC, Moerland PD, Sanders RW, van Gils MJ. Claireaux M, et al. Among authors: copps j. Nat Commun. 2022 Aug 4;13(1):4539. doi: 10.1038/s41467-022-32232-0. Nat Commun. 2022. PMID: 35927266 Free PMC article.
Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB. Torres JL, et al. Among authors: copps j. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2120976119. doi: 10.1073/pnas.2120976119. Epub 2022 May 12. Proc Natl Acad Sci U S A. 2022. PMID: 35549549 Free PMC article.
Structural mapping of antibody landscapes to human betacoronavirus spike proteins.
Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Peña AT, Crowe JE Jr, Ward AB. Bangaru S, et al. Among authors: copps j. Sci Adv. 2022 May 6;8(18):eabn2911. doi: 10.1126/sciadv.abn2911. Epub 2022 May 4. Sci Adv. 2022. PMID: 35507649 Free PMC article.
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Peña AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB. Antanasijevic A, et al. Among authors: copps j. Nat Commun. 2021 Aug 10;12(1):4817. doi: 10.1038/s41467-021-25087-4. Nat Commun. 2021. PMID: 34376662 Free PMC article.
Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein.
van Haaren MM, McCoy LE, Torres JL, Lee W, Cottrell CA, Copps JL, van der Woude P, Yasmeen A, de Taeye SW, Torrents de la Peña A, Moore JP, Burton DR, Klasse PJ, Ward AB, Sanders RW, van Gils MJ. van Haaren MM, et al. Among authors: copps jl. J Virol. 2021 Aug 10;95(17):e0009421. doi: 10.1128/JVI.00094-21. Epub 2021 Aug 10. J Virol. 2021. PMID: 34076487 Free PMC article.
63 results