Cooper RA - Search Results

1

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.

Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Mu J, Bayles BR, Cooper RA, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX. Kancharla P, et al. Among authors: cooper ra. J Med Chem. 2020 Jun 11;63(11):6179-6202. doi: 10.1021/acs.jmedchem.0c00539. Epub 2020 May 26. J Med Chem. 2020. PMID: 32390431 Free PMC article.

2

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.

Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE. Cooper RA, et al. Mol Pharmacol. 2002 Jan;61(1):35-42. doi: 10.1124/mol.61.1.35. Mol Pharmacol. 2002. PMID: 11752204

3

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.

Wootton JC, Feng X, Ferdig MT, Cooper RA, Mu J, Baruch DI, Magill AJ, Su XZ. Wootton JC, et al. Among authors: cooper ra. Nature. 2002 Jul 18;418(6895):320-3. doi: 10.1038/nature00813. Nature. 2002. PMID: 12124623

4

Multiple transporters associated with malaria parasite responses to chloroquine and quinine.

Mu J, Ferdig MT, Feng X, Joy DA, Duan J, Furuya T, Subramanian G, Aravind L, Cooper RA, Wootton JC, Xiong M, Su XZ. Mu J, et al. Among authors: cooper ra. Mol Microbiol. 2003 Aug;49(4):977-89. doi: 10.1046/j.1365-2958.2003.03627.x. Mol Microbiol. 2003. PMID: 12890022 Free article.

5

Dissecting the loci of low-level quinine resistance in malaria parasites.

Ferdig MT, Cooper RA, Mu J, Deng B, Joy DA, Su XZ, Wellems TE. Ferdig MT, et al. Among authors: cooper ra. Mol Microbiol. 2004 May;52(4):985-97. doi: 10.1111/j.1365-2958.2004.04035.x. Mol Microbiol. 2004. PMID: 15130119 Free article.

6

Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.

Kelly JX, Smilkstein MJ, Cooper RA, Lane KD, Johnson RA, Janowsky A, Dodean RA, Hinrichs DJ, Winter R, Riscoe M. Kelly JX, et al. Among authors: cooper ra. Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. doi: 10.1128/AAC.00669-07. Epub 2007 Sep 10. Antimicrob Agents Chemother. 2007. PMID: 17846138 Free PMC article.

7

Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene.

Jiang H, Patel JJ, Yi M, Mu J, Ding J, Stephens R, Cooper RA, Ferdig MT, Su XZ. Jiang H, et al. Among authors: cooper ra. PLoS One. 2008 Jun 25;3(6):e2484. doi: 10.1371/journal.pone.0002484. PLoS One. 2008. PMID: 18575593 Free PMC article.

8

Discovery of dual function acridones as a new antimalarial chemotype.

Kelly JX, Smilkstein MJ, Brun R, Wittlin S, Cooper RA, Lane KD, Janowsky A, Johnson RA, Dodean RA, Winter R, Hinrichs DJ, Riscoe MK. Kelly JX, et al. Among authors: cooper ra. Nature. 2009 May 14;459(7244):270-3. doi: 10.1038/nature07937. Epub 2009 Apr 8. Nature. 2009. PMID: 19357645 Free PMC article.

9

Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.

Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, Kozak B, Bloome J, Okiring J, Kakuru A, Bigira V, Kapisi J, Legac J, Gut J, Cooper RA, Kamya MR, Havlir DV, Dorsey G, Greenhouse B, Nsobya SL, Rosenthal PJ. Tumwebaze P, et al. Among authors: cooper ra. Antimicrob Agents Chemother. 2015;59(6):3018-30. doi: 10.1128/AAC.05141-14. Epub 2015 Mar 9. Antimicrob Agents Chemother. 2015. PMID: 25753626 Free PMC article.

10

Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays.

Cooper RA, Conrad MD, Watson QD, Huezo SJ, Ninsiima H, Tumwebaze P, Nsobya SL, Rosenthal PJ. Cooper RA, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):5061-4. doi: 10.1128/AAC.00921-15. Epub 2015 Jun 1. Antimicrob Agents Chemother. 2015. PMID: 26033725 Free PMC article.

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