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Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor.
Al-Hasani K, Khurana I, Mariana L, Loudovaris T, Maxwell S, Harikrishnan KN, Okabe J, Cooper ME, El-Osta A. Al-Hasani K, et al. Among authors: cooper me. Signal Transduct Target Ther. 2022 Jul 22;7(1):248. doi: 10.1038/s41392-022-01034-7. Signal Transduct Target Ther. 2022. PMID: 35864094 Free PMC article.
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Brasacchio D, Okabe J, Tikellis C, Balcerczyk A, George P, Baker EK, Calkin AC, Brownlee M, Cooper ME, El-Osta A. Brasacchio D, et al. Among authors: cooper me. Diabetes. 2009 May;58(5):1229-36. doi: 10.2337/db08-1666. Epub 2009 Feb 10. Diabetes. 2009. PMID: 19208907 Free PMC article.
NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis.
Gray SP, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, de Haan JB, Koulis C, El-Osta A, Andrews KL, Chin-Dusting JP, Touyz RM, Wingler K, Cooper ME, Schmidt HH, Jandeleit-Dahm KA. Gray SP, et al. Among authors: cooper me. Circulation. 2013 May 7;127(18):1888-902. doi: 10.1161/CIRCULATIONAHA.112.132159. Epub 2013 Apr 5. Circulation. 2013. PMID: 23564668
Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.
Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA. Jha JC, et al. Among authors: cooper me. J Am Soc Nephrol. 2014 Jun;25(6):1237-54. doi: 10.1681/ASN.2013070810. Epub 2014 Feb 7. J Am Soc Nephrol. 2014. PMID: 24511132 Free PMC article.
Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling.
Gray SP, Di Marco E, Kennedy K, Chew P, Okabe J, El-Osta A, Calkin AC, Biessen EA, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA. Gray SP, et al. Among authors: cooper me. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):295-307. doi: 10.1161/ATVBAHA.115.307012. Epub 2015 Dec 29. Arterioscler Thromb Vasc Biol. 2016. PMID: 26715682
708 results