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Furamidine Rescues Myotonic Dystrophy Type I Associated Mis-Splicing through Multiple Mechanisms.
ACS Chem Biol. 2018 Sep 21;13(9):2708-2718. doi: 10.1021/acschembio.8b00646. Epub 2018 Aug 27.
ACS Chem Biol. 2018.
PMID: 30118588
Free PMC article.
Reducing levels of toxic RNA with small molecules.
Coonrod LA, Nakamori M, Wang W, Carrell S, Hilton CL, Bodner MJ, Siboni RB, Docter AG, Haley MM, Thornton CA, Berglund JA.
Coonrod LA, et al.
ACS Chem Biol. 2013 Nov 15;8(11):2528-37. doi: 10.1021/cb400431f. Epub 2013 Sep 27.
ACS Chem Biol. 2013.
PMID: 24028068
Free PMC article.
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Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models.
Siboni RB, Nakamori M, Wagner SD, Struck AJ, Coonrod LA, Harriott SA, Cass DM, Tanner MK, Berglund JA.
Siboni RB, et al. Among authors: coonrod la.
Cell Rep. 2015 Dec 22;13(11):2386-2394. doi: 10.1016/j.celrep.2015.11.028. Epub 2015 Dec 10.
Cell Rep. 2015.
PMID: 26686629
Free PMC article.
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Autoregulated splicing of muscleblind-like 1 (MBNL1) Pre-mRNA.
Gates DP, Coonrod LA, Berglund JA.
Gates DP, et al. Among authors: coonrod la.
J Biol Chem. 2011 Sep 30;286(39):34224-33. doi: 10.1074/jbc.M111.236547. Epub 2011 Aug 9.
J Biol Chem. 2011.
PMID: 21832083
Free PMC article.
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Utilizing the GAAA tetraloop/receptor to facilitate crystal packing and determination of the structure of a CUG RNA helix.
Coonrod LA, Lohman JR, Berglund JA.
Coonrod LA, et al.
Biochemistry. 2012 Oct 23;51(42):8330-7. doi: 10.1021/bi300829w. Epub 2012 Oct 12.
Biochemistry. 2012.
PMID: 23025897
Free PMC article.
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Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model.
deLorimier E, Coonrod LA, Copperman J, Taber A, Reister EE, Sharma K, Todd PK, Guenza MG, Berglund JA.
deLorimier E, et al. Among authors: coonrod la.
Nucleic Acids Res. 2014 Nov 10;42(20):12768-78. doi: 10.1093/nar/gku941. Epub 2014 Oct 10.
Nucleic Acids Res. 2014.
PMID: 25303993
Free PMC article.
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