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Reducing levels of toxic RNA with small molecules.
Coonrod LA, Nakamori M, Wang W, Carrell S, Hilton CL, Bodner MJ, Siboni RB, Docter AG, Haley MM, Thornton CA, Berglund JA. Coonrod LA, et al. ACS Chem Biol. 2013 Nov 15;8(11):2528-37. doi: 10.1021/cb400431f. Epub 2013 Sep 27. ACS Chem Biol. 2013. PMID: 24028068 Free PMC article.
Autoregulated splicing of muscleblind-like 1 (MBNL1) Pre-mRNA.
Gates DP, Coonrod LA, Berglund JA. Gates DP, et al. Among authors: coonrod la. J Biol Chem. 2011 Sep 30;286(39):34224-33. doi: 10.1074/jbc.M111.236547. Epub 2011 Aug 9. J Biol Chem. 2011. PMID: 21832083 Free PMC article.
Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model.
deLorimier E, Coonrod LA, Copperman J, Taber A, Reister EE, Sharma K, Todd PK, Guenza MG, Berglund JA. deLorimier E, et al. Among authors: coonrod la. Nucleic Acids Res. 2014 Nov 10;42(20):12768-78. doi: 10.1093/nar/gku941. Epub 2014 Oct 10. Nucleic Acids Res. 2014. PMID: 25303993 Free PMC article.