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Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine.
Deliyannis G, Gherardin NA, Wong CY, Grimley SL, Cooney JP, Redmond SJ, Ellenberg P, Davidson KC, Mordant FL, Smith T, Gillard M, Lopez E, McAuley J, Tan CW, Wang JJ, Zeng W, Littlejohn M, Zhou R, Fuk-Woo Chan J, Chen ZW, Hartwig AE, Bowen R, Mackenzie JM, Vincan E, Torresi J, Kedzierska K, Pouton CW, Gordon TP, Wang LF, Kent SJ, Wheatley AK, Lewin SR, Subbarao K, Chung AW, Pellegrini M, Munro T, Nolan T, Rockman S, Jackson DC, Purcell DFJ, Godfrey DI. Deliyannis G, et al. Among authors: cooney jp. EBioMedicine. 2023 Jun;92:104574. doi: 10.1016/j.ebiom.2023.104574. Epub 2023 May 4. EBioMedicine. 2023. PMID: 37148585 Free PMC article.
Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus.
Ebert G, Preston S, Allison C, Cooney J, Toe JG, Stutz MD, Ojaimi S, Scott HW, Baschuk N, Nachbur U, Torresi J, Chin R, Colledge D, Li X, Warner N, Revill P, Bowden S, Silke J, Begley CG, Pellegrini M. Ebert G, et al. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5797-802. doi: 10.1073/pnas.1502390112. Epub 2015 Apr 20. Proc Natl Acad Sci U S A. 2015. PMID: 25902529 Free PMC article.
Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis.
Ebert G, Allison C, Preston S, Cooney J, Toe JG, Stutz MD, Ojaimi S, Baschuk N, Nachbur U, Torresi J, Silke J, Begley CG, Pellegrini M. Ebert G, et al. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5803-8. doi: 10.1073/pnas.1502400112. Epub 2015 Apr 20. Proc Natl Acad Sci U S A. 2015. PMID: 25902530 Free PMC article.
Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.
Pymm P, Adair A, Chan LJ, Cooney JP, Mordant FL, Allison CC, Lopez E, Haycroft ER, O'Neill MT, Tan LL, Dietrich MH, Drew D, Doerflinger M, Dengler MA, Scott NE, Wheatley AK, Gherardin NA, Venugopal H, Cromer D, Davenport MP, Pickering R, Godfrey DI, Purcell DFJ, Kent SJ, Chung AW, Subbarao K, Pellegrini M, Glukhova A, Tham WH. Pymm P, et al. Among authors: cooney jp. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2101918118. doi: 10.1073/pnas.2101918118. Proc Natl Acad Sci U S A. 2021. PMID: 33893175 Free PMC article.
Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH. Wheatley AK, et al. Among authors: cooney jp. Cell Rep. 2021 Oct 12;37(2):109822. doi: 10.1016/j.celrep.2021.109822. Epub 2021 Sep 25. Cell Rep. 2021. PMID: 34610292 Free PMC article.
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.
Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L, Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA, Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE, Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE, Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R, Vince JE. Simpson DS, et al. Among authors: cooney jp. Immunity. 2022 Mar 8;55(3):423-441.e9. doi: 10.1016/j.immuni.2022.01.003. Epub 2022 Feb 8. Immunity. 2022. PMID: 35139355 Free PMC article.
Programmed cell death: the pathways to severe COVID-19?
Bader SM, Cooney JP, Pellegrini M, Doerflinger M. Bader SM, et al. Among authors: cooney jp. Biochem J. 2022 Mar 18;479(5):609-628. doi: 10.1042/BCJ20210602. Biochem J. 2022. PMID: 35244141 Free PMC article. Review.
Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2.
Wines BD, Kurtovic L, Trist HM, Esparon S, Lopez E, Chappin K, Chan LJ, Mordant FL, Lee WS, Gherardin NA, Patel SK, Hartley GE, Pymm P, Cooney JP, Beeson JG, Godfrey DI, Burrell LM, van Zelm MC, Wheatley AK, Chung AW, Tham WH, Subbarao K, Kent SJ, Hogarth PM. Wines BD, et al. Among authors: cooney jp. Front Immunol. 2022 Jul 28;13:889372. doi: 10.3389/fimmu.2022.889372. eCollection 2022. Front Immunol. 2022. PMID: 35967361 Free PMC article.
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