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LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes.
Kawakami F, Imai M, Isaka Y, Cookson MR, Maruyama H, Kubo M, Farrer MJ, Kanzaki M, Kawashima R, Maekawa T, Tamaki S, Kurosaki Y, Kojima F, Ohba K, Ichikawa T. Kawakami F, et al. Among authors: cookson mr. FEBS Open Bio. 2023 Dec;13(12):2200-2214. doi: 10.1002/2211-5463.13717. Epub 2023 Oct 26. FEBS Open Bio. 2023. PMID: 37845194 Free PMC article.
LRRK2 recruitment, activity, and function in organelles.
Bonet-Ponce L, Cookson MR. Bonet-Ponce L, et al. Among authors: cookson mr. FEBS J. 2022 Nov;289(22):6871-6890. doi: 10.1111/febs.16099. Epub 2021 Jul 14. FEBS J. 2022. PMID: 34196120 Free PMC article. Review.
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR. Greggio E, et al. Among authors: cookson mr. Biochem Biophys Res Commun. 2009 Nov 20;389(3):449-54. doi: 10.1016/j.bbrc.2009.08.163. Epub 2009 Sep 3. Biochem Biophys Res Commun. 2009. PMID: 19733152 Free PMC article.
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
Hsu CH, Chan D, Greggio E, Saha S, Guillily MD, Ferree A, Raghavan K, Shen GC, Segal L, Ryu H, Cookson MR, Wolozin B. Hsu CH, et al. Among authors: cookson mr. J Neurochem. 2010 Mar;112(6):1593-604. doi: 10.1111/j.1471-4159.2010.06568.x. Epub 2010 Jan 7. J Neurochem. 2010. PMID: 20067578 Free PMC article.
Role of LRRK2 kinase dysfunction in Parkinson disease.
Kumar A, Cookson MR. Kumar A, et al. Among authors: cookson mr. Expert Rev Mol Med. 2011 Jun 13;13:e20. doi: 10.1017/S146239941100192X. Expert Rev Mol Med. 2011. PMID: 21676337 Free PMC article. Review.
Cellular effects of LRRK2 mutations.
Cookson MR. Cookson MR. Biochem Soc Trans. 2012 Oct;40(5):1070-3. doi: 10.1042/BST20120165. Biochem Soc Trans. 2012. PMID: 22988867 Free PMC article. Review.
335 results