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Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors.
Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM. Cox ED, et al. Among authors: cook jm. J Med Chem. 1998 Jul 2;41(14):2537-52. doi: 10.1021/jm970460b. J Med Chem. 1998. PMID: 9651158
Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis.
Huang Q, Liu R, Zhang P, He X, McKernan R, Gan T, Bennett DW, Cook JM. Huang Q, et al. Among authors: cook jm. J Med Chem. 1998 Oct 8;41(21):4130-42. doi: 10.1021/jm980317y. J Med Chem. 1998. PMID: 9767648
Studies of molecular pharmacophore/receptor models for GABAA/benzodiazepine receptor subtypes: binding affinities of substituted beta-carbolines at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis.
Huang Q, Cox ED, Gan T, Ma C, Bennett DW, McKernan RM, Cook JM. Huang Q, et al. Among authors: cook jm. Drug Des Discov. 1999 Jul;16(1):55-76. Drug Des Discov. 1999. PMID: 10466057
Studies of molecular pharmacophore/receptor models for GABAA/BzR subtypes: binding affinities of symmetrically substituted pyrazolo[4,3-c]quinolin-3-ones at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis.
He X, Huang Q, Yu S, Ma C, McKernan R, Cook JM. He X, et al. Among authors: cook jm. Drug Des Discov. 1999 Jul;16(1):77-91. Drug Des Discov. 1999. PMID: 10466058
A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.
Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, Weed MR, Cook JM. Han D, et al. Among authors: cook jm. Bioorg Med Chem. 2008 Oct 1;16(19):8853-62. doi: 10.1016/j.bmc.2008.08.072. Epub 2008 Sep 2. Bioorg Med Chem. 2008. PMID: 18790643 Free PMC article.
Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.
Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM. Yin W, et al. Among authors: cook jm. Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. doi: 10.1016/j.bmc.2010.08.049. Epub 2010 Sep 29. Bioorg Med Chem. 2010. PMID: 20888240 Free PMC article.
613 results