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Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration.
Shao W, Todd TW, Wu Y, Jones CY, Tong J, Jansen-West K, Daughrity LM, Park J, Koike Y, Kurti A, Yue M, Castanedes-Casey M, Del Rosso G, Dunmore JA, Zanetti Alepuz D, Oskarsson B, Dickson DW, Cook CN, Prudencio M, Gendron TF, Fryer JD, Zhang YJ, Petrucelli L. Shao W, et al. Among authors: cook cn. Science. 2022 Oct 7;378(6615):94-99. doi: 10.1126/science.abq7860. Epub 2022 Oct 6. Science. 2022. PMID: 36201573 Free PMC article.
TDP-43 in neurodegenerative disorders.
Cook C, Zhang YJ, Xu YF, Dickson DW, Petrucelli L. Cook C, et al. Expert Opin Biol Ther. 2008 Jul;8(7):969-78. doi: 10.1517/14712598.8.7.969. Expert Opin Biol Ther. 2008. PMID: 18549326 Free PMC article. Review.
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, Dickson DW, Petrucelli L. Zhang YJ, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7607-12. doi: 10.1073/pnas.0900688106. Epub 2009 Apr 21. Proc Natl Acad Sci U S A. 2009. PMID: 19383787 Free PMC article.
Disruption of protein quality control in Parkinson's disease.
Cook C, Stetler C, Petrucelli L. Cook C, et al. Cold Spring Harb Perspect Med. 2012 May;2(5):a009423. doi: 10.1101/cshperspect.a009423. Cold Spring Harb Perspect Med. 2012. PMID: 22553500 Free PMC article. Review.
Progranulin regulates neuronal outgrowth independent of sortilin.
Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L. Gass J, et al. Mol Neurodegener. 2012 Jul 10;7:33. doi: 10.1186/1750-1326-7-33. Mol Neurodegener. 2012. PMID: 22781549 Free PMC article.
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, Petrucelli L, Sahara N, Dickson DW, Giasson B, Lewis J. Clippinger AK, et al. Acta Neuropathol. 2013 Jul;126(1):39-50. doi: 10.1007/s00401-013-1123-8. Epub 2013 May 11. Acta Neuropathol. 2013. PMID: 23666556 Free PMC article.
124 results