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Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications.
Favalli N, Bassi G, Pellegrino C, Millul J, De Luca R, Cazzamalli S, Yang S, Trenner A, Mozaffari NL, Myburgh R, Moroglu M, Conway SJ, Sartori AA, Manz MG, Lerner RA, Vogt PK, Scheuermann J, Neri D. Favalli N, et al. Among authors: conway sj. Nat Chem. 2021 Jun;13(6):540-548. doi: 10.1038/s41557-021-00660-y. Epub 2021 Apr 8. Nat Chem. 2021. PMID: 33833446 Free PMC article.
A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks.
Bassi G, Favalli N, Vuk M, Catalano M, Martinelli A, Trenner A, Porro A, Yang S, Tham CL, Moroglu M, Yue WW, Conway SJ, Vogt PK, Sartori AA, Scheuermann J, Neri D. Bassi G, et al. Among authors: conway sj. Adv Sci (Weinh). 2020 Oct 14;7(22):2001970. doi: 10.1002/advs.202001970. eCollection 2020 Nov. Adv Sci (Weinh). 2020. PMID: 33240760 Free PMC article.
Publisher Correction: Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications.
Favalli N, Bassi G, Pellegrino C, Millul J, De Luca R, Cazzamalli S, Yang S, Trenner A, Mozaffari NL, Myburgh R, Moroglu M, Conway SJ, Sartori AA, Manz MG, Lerner RA, Vogt PK, Scheuermann J, Neri D. Favalli N, et al. Among authors: conway sj. Nat Chem. 2021 Jul;13(7):714. doi: 10.1038/s41557-021-00742-x. Nat Chem. 2021. PMID: 34103693 No abstract available.
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, Perell G, Kalra P, Vinh KB, Cortopassi WA, Heitel P, Christensen KE, Cooper RI, Paton RS, Pomerantz WCK, Biggin PC, Hammond EM, Filippakopoulos P, Conway SJ. Brand M, et al. Among authors: conway sj. J Med Chem. 2021 Jul 22;64(14):10102-10123. doi: 10.1021/acs.jmedchem.1c00348. Epub 2021 Jul 13. J Med Chem. 2021. PMID: 34255515 Free PMC article.
Epigenetics: novel therapeutics targeting epigenetics.
Conway SJ, Woster PM, Shen JK, Georg G, Wang S. Conway SJ, et al. J Med Chem. 2015 Jan 22;58(2):523-4. doi: 10.1021/jm501941q. Epub 2014 Dec 22. J Med Chem. 2015. PMID: 25532017 No abstract available.
Epigenetics: Novel Therapeutics Targeting Epigenetics.
Conway SJ, Woster PM, Greenlee WJ, Georg G, Wang S. Conway SJ, et al. J Med Chem. 2016 Feb 25;59(4):1247-8. doi: 10.1021/acs.jmedchem.6b00098. Epub 2016 Jan 29. J Med Chem. 2016. PMID: 26824165 No abstract available.
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, Evans CNG, Stazi G, Biggin PC, Mapp AK, Hammond EM, Humphreys PG, Filippakopoulos P, Conway SJ. Jennings LE, et al. Among authors: conway sj. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957. doi: 10.1016/j.bmc.2018.05.003. Epub 2018 May 15. Bioorg Med Chem. 2018. PMID: 29776834 Free article.
333 results