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Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion.
Sci Immunol. 2023 Dec 15;8(90):eabo5558. doi: 10.1126/sciimmunol.abo5558. Epub 2023 Dec 15.
Sci Immunol. 2023.
PMID: 38100544
Free PMC article.
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function.
Whiteside SK, Grant FM, Gyori DS, Conti AG, Imianowski CJ, Kuo P, Nasrallah R, Sadiyah F, Lira SA, Tacke F, Eil RL, Burton OT, Dooley J, Liston A, Okkenhaug K, Yang J, Roychoudhuri R.
Whiteside SK, et al. Among authors: conti ag.
Immunology. 2021 Aug;163(4):512-520. doi: 10.1111/imm.13337. Epub 2021 May 9.
Immunology. 2021.
PMID: 33838058
Free PMC article.
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Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy.
Conti AG, Roychoudhuri R.
Conti AG, et al.
Nat Immunol. 2023 May;24(5):733-735. doi: 10.1038/s41590-023-01470-9.
Nat Immunol. 2023.
PMID: 37081149
No abstract available.
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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S.
Gaggero S, et al. Among authors: conti ag.
Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2.
Sci Immunol. 2022.
PMID: 36459543
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