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Ion Channels in Drug Discovery and Safety Pharmacology.
Imbrici P, Nicolotti O, Leonetti F, Conte D, Liantonio A. Imbrici P, et al. Among authors: conte d. Methods Mol Biol. 2018;1800:313-326. doi: 10.1007/978-1-4939-7899-1_15. Methods Mol Biol. 2018. PMID: 29934900 Review.
Mapping ligand binding pockets in chloride ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid.
Altamura C, Mangiatordi GF, Nicolotti O, Sahbani D, Farinato A, Leonetti F, Carratù MR, Conte D, Desaphy JF, Imbrici P. Altamura C, et al. Among authors: conte d. Br J Pharmacol. 2018 May;175(10):1770-1780. doi: 10.1111/bph.14192. Epub 2018 Apr 6. Br J Pharmacol. 2018. PMID: 29500929 Free PMC article.
Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery.
Imbrici P, Liantonio A, Camerino GM, De Bellis M, Camerino C, Mele A, Giustino A, Pierno S, De Luca A, Tricarico D, Desaphy JF, Conte D. Imbrici P, et al. Among authors: conte d. Front Pharmacol. 2016 May 10;7:121. doi: 10.3389/fphar.2016.00121. eCollection 2016. Front Pharmacol. 2016. PMID: 27242528 Free PMC article. Review.
Skeletal muscle ClC-1 chloride channels in health and diseases.
Altamura C, Desaphy JF, Conte D, De Luca A, Imbrici P. Altamura C, et al. Among authors: conte d. Pflugers Arch. 2020 Jul;472(7):961-975. doi: 10.1007/s00424-020-02376-3. Epub 2020 May 2. Pflugers Arch. 2020. PMID: 32361781 Review.
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions.
Imbrici P, Altamura C, Gualandi F, Mangiatordi GF, Neri M, De Maria G, Ferlini A, Padovani A, D'Adamo MC, Nicolotti O, Pessia M, Conte D, Filosto M, Desaphy JF. Imbrici P, et al. Among authors: conte d, d adamo mc. Mol Cell Neurosci. 2017 Sep;83:6-12. doi: 10.1016/j.mcn.2017.06.006. Epub 2017 Jun 28. Mol Cell Neurosci. 2017. PMID: 28666963
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo.
Desaphy JF, Farinato A, Altamura C, De Bellis M, Imbrici P, Tarantino N, Caccia C, Melloni E, Padoani G, Vailati S, Keywood C, Carratù MR, De Luca A, Conte D, Pierno S. Desaphy JF, et al. Among authors: conte d. Exp Neurol. 2020 Jun;328:113287. doi: 10.1016/j.expneurol.2020.113287. Epub 2020 Mar 20. Exp Neurol. 2020. PMID: 32205118
The analysis of myotonia congenita mutations discloses functional clusters of amino acids within the CBS2 domain and the C-terminal peptide of the ClC-1 channel.
Altamura C, Lucchiari S, Sahbani D, Ulzi G, Comi GP, D'Ambrosio P, Petillo R, Politano L, Vercelli L, Mongini T, Dotti MT, Cardani R, Meola G, Lo Monaco M, Matthews E, Hanna MG, Carratù MR, Conte D, Imbrici P, Desaphy JF. Altamura C, et al. Among authors: conte d, d ambrosio p. Hum Mutat. 2018 Sep;39(9):1273-1283. doi: 10.1002/humu.23581. Epub 2018 Jul 4. Hum Mutat. 2018. PMID: 29935101 Free article.
598 results