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Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol.
Feng W, Qin C, Abdelrazig S, Bai Z, Raji M, Darwish R, Chu Y, Ji L, Gray DA, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Among authors: constantinescu cs. Int J Pharm. 2022 Aug 25;624:121947. doi: 10.1016/j.ijpharm.2022.121947. Epub 2022 Jun 23. Int J Pharm. 2022. PMID: 35753538 Free article.
Plasma endocannabinoid levels in multiple sclerosis.
Jean-Gilles L, Feng S, Tench CR, Chapman V, Kendall DA, Barrett DA, Constantinescu CS. Jean-Gilles L, et al. Among authors: constantinescu cs. J Neurol Sci. 2009 Dec 15;287(1-2):212-5. doi: 10.1016/j.jns.2009.07.021. Epub 2009 Aug 20. J Neurol Sci. 2009. PMID: 19695579
Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.
Zgair A, Lee JB, Wong JCM, Taha DA, Aram J, Di Virgilio D, McArthur JW, Cheng YK, Hennig IM, Barrett DA, Fischer PM, Constantinescu CS, Gershkovich P. Zgair A, et al. Among authors: constantinescu cs. Sci Rep. 2017 Nov 6;7(1):14542. doi: 10.1038/s41598-017-15026-z. Sci Rep. 2017. PMID: 29109461 Free PMC article.
Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol.
Feng W, Qin C, Chu Y, Berton M, Lee JB, Zgair A, Bettonte S, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Among authors: constantinescu cs. Eur J Pharm Biopharm. 2021 May;162:43-49. doi: 10.1016/j.ejpb.2021.02.013. Epub 2021 Mar 5. Eur J Pharm Biopharm. 2021. PMID: 33677067
Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle.
Feng W, Qin C, Cipolla E, Lee JB, Zgair A, Chu Y, Ortori CA, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Among authors: constantinescu cs. Pharmaceutics. 2021 Aug 27;13(9):1349. doi: 10.3390/pharmaceutics13091349. Pharmaceutics. 2021. PMID: 34575426 Free PMC article.
230 results