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MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control.
Heiland M, Connolly NMC, Mamad O, Nguyen NT, Kesavan JC, Langa E, Fanning K, Sanfeliu A, Yan Y, Su J, Venø MT, Costard LS, Neubert V, Engel T, Hill TDM, Freiman TM, Mahesh A, Tiwari VK, Rosenow F, Bauer S, Kjems J, Morris G, Henshall DC. Heiland M, et al. Among authors: connolly nmc. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2216658120. doi: 10.1073/pnas.2216658120. Epub 2023 Jul 18. Proc Natl Acad Sci U S A. 2023. PMID: 37463203 Free PMC article.
Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons.
Theurey P, Connolly NMC, Fortunati I, Basso E, Lauwen S, Ferrante C, Moreira Pinho C, Joselin A, Gioran A, Bano D, Park DS, Ankarcrona M, Pizzo P, Prehn JHM. Theurey P, et al. Among authors: connolly nmc. Aging Cell. 2019 Jun;18(3):e12924. doi: 10.1111/acel.12924. Epub 2019 Feb 21. Aging Cell. 2019. PMID: 30793475 Free PMC article.
Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus.
Raoof R, Jimenez-Mateos EM, Bauer S, Tackenberg B, Rosenow F, Lang J, Onugoren MD, Hamer H, Huchtemann T, Körtvélyessy P, Connolly NMC, Pfeiffer S, Prehn JHM, Farrell MA, O'Brien DF, Henshall DC, Mooney C. Raoof R, et al. Among authors: connolly nmc. Sci Rep. 2017 Jun 12;7(1):3328. doi: 10.1038/s41598-017-02969-6. Sci Rep. 2017. PMID: 28607431 Free PMC article.
Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy.
Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC. Raoof R, et al. Among authors: connolly nmc. EBioMedicine. 2018 Dec;38:127-141. doi: 10.1016/j.ebiom.2018.10.068. Epub 2018 Nov 2. EBioMedicine. 2018. PMID: 30396857 Free PMC article.
GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model.
Liu J, McDaid L, Araque A, Wade J, Harkin J, Karim S, Henshall DC, Connolly NMC, Johnson AP, Tyrrell AM, Timmis J, Millard AG, Hilder J, Halliday DM. Liu J, et al. Among authors: connolly nmc. Front Cell Neurosci. 2019 Jul 23;13:335. doi: 10.3389/fncel.2019.00335. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31396055 Free PMC article.
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR, Sanz-Rodriguez A, Muilu J, Fabene PF, Pasterkamp RJ, Prehn JHM, Schorge S, Andersen JS, Rosenow F, Bauer S, Kjems J, Henshall DC. Venø MT, et al. Among authors: connolly nmc. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15977-15988. doi: 10.1073/pnas.1919313117. Epub 2020 Jun 24. Proc Natl Acad Sci U S A. 2020. PMID: 32581127 Free PMC article.
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Brennan GP, Bauer S, Engel T, Jimenez-Mateos EM, Del Gallo F, Hill TDM, Connolly NMC, Costard LS, Neubert V, Salvetti B, Sanz-Rodriguez A, Heiland M, Mamad O, Brindley E, Norwood B, Batool A, Raoof R, El-Naggar H, Reschke CR, Delanty N, Prehn JHM, Fabene P, Mooney C, Rosenow F, Henshall DC. Brennan GP, et al. Among authors: connolly nmc. Neurobiol Dis. 2020 Oct;144:105048. doi: 10.1016/j.nbd.2020.105048. Epub 2020 Aug 13. Neurobiol Dis. 2020. PMID: 32800995 Free article.
Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.
Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC. Reschke CR, et al. Among authors: connolly nmc. Mol Ther. 2021 Jun 2;29(6):2041-2052. doi: 10.1016/j.ymthe.2021.02.021. Epub 2021 Feb 18. Mol Ther. 2021. PMID: 33609732 Free PMC article.
27 results