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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ. Ryan TAJ, et al. Among authors: conlon n. Nat Commun. 2023 Jun 14;14(1):3513. doi: 10.1038/s41467-023-39174-1. Nat Commun. 2023. PMID: 37316487 Free PMC article.
Spatial and Temporal Clustering of Anti-Glomerular Basement Membrane Disease.
Canney M, O'Hara PV, McEvoy CM, Medani S, Connaughton DM, Abdalla AA, Doyle R, Stack AG, O'Seaghdha CM, Clarkson MR, Griffin MD, Holian J, Dorman AM, Niland A, Keogan M, Wallace EM, Conlon NP, Walsh C, Kelly A, Little MA. Canney M, et al. Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1392-1399. doi: 10.2215/CJN.13591215. Epub 2016 Jul 11. Clin J Am Soc Nephrol. 2016. PMID: 27401523 Free PMC article.
Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health.
Townsend L, Dyer AH, Naughton A, Kiersey R, Holden D, Gardiner M, Dowds J, O'Brien K, Bannan C, Nadarajan P, Dunne J, Martin-Loeches I, Fallon PG, Bergin C, O'Farrelly C, Cheallaigh CN, Bourke NM, Conlon N. Townsend L, et al. Among authors: conlon n. Front Immunol. 2021 May 7;12:676932. doi: 10.3389/fimmu.2021.676932. eCollection 2021. Front Immunol. 2021. PMID: 34025675 Free PMC article.
Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression.
Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Hennessy M, Byrne D, Browne P, Bacon CL, Doyle C, O'Riordan R, McLaughlin AM, Bannan C, Martin-Loeches I, White A, McLoughlin RM, Bergin C, Bourke NM, O'Farrelly C, Conlon N, Cheallaigh CN; STAR COVID Bioresource. Townsend L, et al. Among authors: conlon n. Heliyon. 2022 Apr;8(4):e09230. doi: 10.1016/j.heliyon.2022.e09230. Epub 2022 Apr 1. Heliyon. 2022. PMID: 35386227 Free PMC article.
171 results