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Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.
Matsumoto Y, La Rose J, Lim M, Adissu HA, Law N, Mao X, Cong F, Mera P, Karsenty G, Goltzman D, Changoor A, Zhang L, Stajkowski M, Grynpas MD, Bergmann C, Rottapel R. Matsumoto Y, et al. Among authors: cong f. J Clin Invest. 2017 Jun 30;127(7):2612-2625. doi: 10.1172/JCI92233. Epub 2017 Jun 5. J Clin Invest. 2017. PMID: 28581440 Free PMC article.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F. Hao HX, et al. Among authors: cong f. Nature. 2012 Apr 29;485(7397):195-200. doi: 10.1038/nature11019. Nature. 2012. PMID: 22575959
The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS. Planas-Paz L, et al. Among authors: cong f. Nat Cell Biol. 2016 May;18(5):467-79. doi: 10.1038/ncb3337. Epub 2016 Apr 18. Nat Cell Biol. 2016. PMID: 27088858
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Jiang X, Hao HX, Growney JD, Woolfenden S, Bottiglio C, Ng N, Lu B, Hsieh MH, Bagdasarian L, Meyer R, Smith TR, Avello M, Charlat O, Xie Y, Porter JA, Pan S, Liu J, McLaughlin ME, Cong F. Jiang X, et al. Among authors: cong f. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54. doi: 10.1073/pnas.1307218110. Epub 2013 Jul 11. Proc Natl Acad Sci U S A. 2013. PMID: 23847203 Free PMC article.
310 results