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Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.
Biswas S, Mandal G, Anadon CM, Chaurio RA, Lopez-Bailon LU, Nagy MZ, Mine JA, Hänggi K, Sprenger KB, Innamarato P, Harro CM, Powers JJ, Johnson J, Fang B, Eysha M, Nan X, Li R, Perez BA, Curiel TJ, Yu X, Rodriguez PC, Conejo-Garcia JR. Biswas S, et al. Among authors: conejo garcia jr. Immunity. 2023 Nov 14;56(11):2570-2583.e6. doi: 10.1016/j.immuni.2023.09.013. Epub 2023 Oct 30. Immunity. 2023. PMID: 37909039 Free article.
Neglected no more: B cell-mediated anti-tumor immunity.
Conejo-Garcia JR, Biswas S, Chaurio R, Rodriguez PC. Conejo-Garcia JR, et al. Semin Immunol. 2023 Jan;65:101707. doi: 10.1016/j.smim.2022.101707. Epub 2022 Dec 15. Semin Immunol. 2023. PMID: 36527759 Free PMC article. Review.
Dose-Limiting Pulmonary Toxicity in a Phase 1/2 Study of Radiation and Chemotherapy with Ipilimumab Followed by Nivolumab for Patients With Stage 3 Unresectable Non-Small Cell Lung Cancer.
Liveringhouse CL, Latifi K, Asous AG, Lam NB, Rosenberg SA, Dilling TJ, MacMillan GV, Chiappori AA, Haura EB, Creelan B, Gray JE, Tanvetyanon T, Shafique MR, Saltos AN, Weiner AA, Clarke J, Kelsey CR, Kim S, Caudell JJ, Rose TA, Conejo-Garcia JR, Li J, Schell MJ, Antonia SJ, Perez BA. Liveringhouse CL, et al. Int J Radiat Oncol Biol Phys. 2023 Jul 15;116(4):837-848. doi: 10.1016/j.ijrobp.2023.01.006. Epub 2023 Jan 17. Int J Radiat Oncol Biol Phys. 2023. PMID: 36657497 Clinical Trial.
Actionable spontaneous antibody responses antagonize malignant progression in ovarian carcinoma.
Handley KF, Mehta S, Martin AL, Biswas S, Maharaj K, Nagy MZ, Mine JA, Cortina C, Yu X, Sprenger K, Mandal G, Innamarato P, Powers JJ, Harro CM, Chaurio RA, Anadon CM, Shahzad MM, Flores I, Conejo-Garcia JR. Handley KF, et al. Gynecol Oncol. 2023 Jun;173:114-121. doi: 10.1016/j.ygyno.2023.03.020. Epub 2023 Apr 28. Gynecol Oncol. 2023. PMID: 37121178 Free article.
Sézary syndrome originates from heavily mutated hematopoietic progenitors.
Harro CM, Sprenger KB, Chaurio RA, Powers JJ, Innamarato P, Anadon CM, Zhang Y, Biswas S, Mandal G, Mine JA, Cortina C, Nagy MZ, Martin AL, Handley KF, Borjas GJ, Chen PL, Pinilla-Ibarz J, Sokol L, Yu X, Conejo-Garcia JR. Harro CM, et al. Blood Adv. 2023 Sep 26;7(18):5586-5602. doi: 10.1182/bloodadvances.2022008562. Blood Adv. 2023. PMID: 37531660 Free PMC article.
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
Mandula JK, Sierra-Mondragon RA, Jimenez RV, Chang D, Mohamed E, Chang S, Vazquez-Martinez JA, Cao Y, Anadon CM, Lee SB, Das S, Rocha-Munguba L, Pham VM, Li R, Tarhini AA, Furqan M, Dalton W, Churchman M, Moran-Segura CM, Nguyen J, Perez B, Kojetin DJ, Obermayer A, Yu X, Chen A, Shaw TI, Conejo-Garcia JR, Rodriguez PC. Mandula JK, et al. Among authors: conejo garcia jr. Immunity. 2024 Apr 11:S1074-7613(24)00141-9. doi: 10.1016/j.immuni.2024.03.020. Online ahead of print. Immunity. 2024. PMID: 38636522
Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma.
De Leo A, Ugolini A, Yu X, Scirocchi F, Scocozza D, Peixoto B, Pace A, D'Angelo L, Liu JKC, Etame AB, Rughetti A, Nuti M, Santoro A, Vogelbaum MA, Conejo-Garcia JR, Rodriguez PC, Veglia F. De Leo A, et al. Among authors: conejo garcia jr. Immunity. 2024 Apr 30:S1074-7613(24)00211-5. doi: 10.1016/j.immuni.2024.04.006. Online ahead of print. Immunity. 2024. PMID: 38703775
170 results