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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B. Gong GQ, et al. Among authors: conduit se. Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24. Nature. 2023. PMID: 37225977 Free PMC article.
Phosphoinositide lipids in primary cilia biology.
Conduit SE, Vanhaesebroeck B. Conduit SE, et al. Biochem J. 2020 Sep 30;477(18):3541-3565. doi: 10.1042/BCJ20200277. Biochem J. 2020. PMID: 32970140 Free PMC article. Review.
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Carroll B, et al. Among authors: conduit se. J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31. J Cell Biol. 2017. PMID: 28566325 Free PMC article.
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
Dyson JM, Conduit SE, Feeney SJ, Hakim S, DiTommaso T, Fulcher AJ, Sriratana A, Ramm G, Horan KA, Gurung R, Wicking C, Smyth I, Mitchell CA. Dyson JM, et al. Among authors: conduit se. J Cell Biol. 2017 Jan 2;216(1):247-263. doi: 10.1083/jcb.201511055. Epub 2016 Dec 20. J Cell Biol. 2017. PMID: 27998989 Free PMC article.
Inositol polyphosphate phosphatases in human disease.
Hakim S, Bertucci MC, Conduit SE, Vuong DL, Mitchell CA. Hakim S, et al. Among authors: conduit se. Curr Top Microbiol Immunol. 2012;362:247-314. doi: 10.1007/978-94-007-5025-8_12. Curr Top Microbiol Immunol. 2012. PMID: 23086422 Review.
12 results