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Page 1
Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture.
Sun J, Singh P, Shami A, Kluza E, Pan M, Djordjevic D, Michaelsen NB, Kennbäck C, van der Wel NN, Orho-Melander M, Nilsson J, Formentini I, Conde-Knape K, Lutgens E, Edsfeldt A, Gonçalves I. Sun J, et al. Among authors: conde knape k. J Am Coll Cardiol. 2023 Jun 13;81(23):2213-2227. doi: 10.1016/j.jacc.2023.04.008. J Am Coll Cardiol. 2023. PMID: 37286250
A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?
Rakipovski G, Rolin B, Barascuk N, Lund HE, Bjørn Bonde MF, Djordjevic D, Wulff-Larsen PG, Petersen M, Kirk RK, Hultman K, Manfe V, Blume N, Zahn S, Lengquist M, Maegdefessel L, Hovingh GK, Conde-Knape K, Hedin U, Matic L, Nyberg M. Rakipovski G, et al. Among authors: conde knape k. Atherosclerosis. 2020 Dec;314:1-9. doi: 10.1016/j.atherosclerosis.2020.10.001. Epub 2020 Oct 6. Atherosclerosis. 2020. PMID: 33129080
BMP7-induced-Pten inhibits Akt and prevents renal fibrosis.
Higgins DF, Ewart LM, Masterson E, Tennant S, Grebnev G, Prunotto M, Pomposiello S, Conde-Knape K, Martin FM, Godson C. Higgins DF, et al. Among authors: conde knape k. Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3095-3104. doi: 10.1016/j.bbadis.2017.09.011. Epub 2017 Sep 18. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28923783 Free article.
Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.
Raab S, Wang H, Uhles S, Cole N, Alvarez-Sanchez R, Künnecke B, Ullmer C, Matile H, Bedoucha M, Norcross RD, Ottaway-Parker N, Perez-Tilve D, Conde Knape K, Tschöp MH, Hoener MC, Sewing S. Raab S, et al. Among authors: conde knape k. Mol Metab. 2015 Nov 1;5(1):47-56. doi: 10.1016/j.molmet.2015.09.015. eCollection 2016 Jan. Mol Metab. 2015. PMID: 26844206 Free PMC article.
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: conde knape k. Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485909
Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
Gillespie P, Pietranico-Cole S, Myers M, Bilotta JA, Conde-Knape K, Fotouhi N, Goodnow RA Jr, Guertin KR, Hamilton MM, Haynes NE, Liu B, Qi L, Ren Y, Scott NR, So SS, Spence C, Taub R, Thakkar K, Tilley JW, Zwingelstein C. Gillespie P, et al. Among authors: conde knape k. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2707-11. doi: 10.1016/j.bmcl.2014.04.049. Epub 2014 Apr 21. Bioorg Med Chem Lett. 2014. PMID: 24815509
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.
Kelly MJ, Pietranico-Cole S, Larigan JD, Haynes NE, Reynolds CH, Scott N, Vermeulen J, Dvorozniak M, Conde-Knape K, Huang KS, So SS, Thakkar K, Qian Y, Banner B, Mennona F, Danzi S, Klein I, Taub R, Tilley J. Kelly MJ, et al. Among authors: conde knape k. J Med Chem. 2014 May 22;57(10):3912-23. doi: 10.1021/jm4019299. Epub 2014 Apr 8. J Med Chem. 2014. PMID: 24712661
Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists.
Gillespie P, Goodnow RA Jr, Saha G, Bose G, Moulik K, Zwingelstein C, Myers M, Conde-Knape K, Pietranico-Cole S, So SS. Gillespie P, et al. Among authors: conde knape k. Bioorg Med Chem Lett. 2014 Feb 1;24(3):949-53. doi: 10.1016/j.bmcl.2013.12.063. Epub 2013 Dec 24. Bioorg Med Chem Lett. 2014. PMID: 24412066
27 results