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Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia--RSV recombinants or RSV.
Connors M, Collins PL, Firestone CY, Sotnikov AV, Waitze A, Davis AR, Hung PP, Chanock RM, Murphy BR. Connors M, et al. Among authors: collins pl. Vaccine. 1992;10(7):475-84. doi: 10.1016/0264-410x(92)90397-3. Vaccine. 1992. PMID: 1609551
Resistance to respiratory syncytial virus (RSV) challenge induced by infection with a vaccinia virus recombinant expressing the RSV M2 protein (Vac-M2) is mediated by CD8+ T cells, while that induced by Vac-F or Vac-G recombinants is mediated by antibodies.
Connors M, Kulkarni AB, Collins PL, Firestone CY, Holmes KL, Morse HC 3rd, Murphy BR. Connors M, et al. Among authors: collins pl. J Virol. 1992 Feb;66(2):1277-81. doi: 10.1128/JVI.66.2.1277-1281.1992. J Virol. 1992. PMID: 1731105 Free PMC article.
441 results