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Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL. Jaye MC, et al. Among authors: collins jl. J Med Chem. 2005 Aug 25;48(17):5419-22. doi: 10.1021/jm050532w. J Med Chem. 2005. PMID: 16107141
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Chao EY, Caravella JA, Watson MA, Campobasso N, Ghisletti S, Billin AN, Galardi C, Wang P, Laffitte BA, Iannone MA, Goodwin BJ, Nichols JA, Parks DJ, Stewart E, Wiethe RW, Williams SP, Smallwood A, Pearce KH, Glass CK, Willson TM, Zuercher WJ, Collins JL. Chao EY, et al. Among authors: collins jl. J Med Chem. 2008 Sep 25;51(18):5758-65. doi: 10.1021/jm800612u. J Med Chem. 2008. PMID: 18800767
Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.
Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA. Whitney KD, et al. Among authors: collins jl. J Biol Chem. 2001 Nov 23;276(47):43509-15. doi: 10.1074/jbc.M106155200. Epub 2001 Aug 23. J Biol Chem. 2001. PMID: 11546778 Free article.
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.
Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG. Leesnitzer LM, et al. Among authors: collins jl. Biochemistry. 2002 May 28;41(21):6640-50. doi: 10.1021/bi0159581. Biochemistry. 2002. PMID: 12022867
277 results