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The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. Wenzel J, et al. Among authors: collin l. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. Nat Neurosci. 2021. PMID: 34675436 Free PMC article.
Region-specific permeability of the blood-brain barrier upon pericyte loss.
Villaseñor R, Kuennecke B, Ozmen L, Ammann M, Kugler C, Grüninger F, Loetscher H, Freskgård PO, Collin L. Villaseñor R, et al. Among authors: collin l. J Cereb Blood Flow Metab. 2017 Dec;37(12):3683-3694. doi: 10.1177/0271678X17697340. Epub 2017 Mar 1. J Cereb Blood Flow Metab. 2017. PMID: 28273726 Free PMC article.
Sorting Tubules Regulate Blood-Brain Barrier Transcytosis.
Villaseñor R, Schilling M, Sundaresan J, Lutz Y, Collin L. Villaseñor R, et al. Among authors: collin l. Cell Rep. 2017 Dec 12;21(11):3256-3270. doi: 10.1016/j.celrep.2017.11.055. Cell Rep. 2017. PMID: 29241551 Free article.
107 results