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PVRIG is expressed on stem-like T cells in dendritic cell-rich niches in tumors and its blockade may induce immune infiltration in non-inflamed tumors.
Alteber Z, Cojocaru G, Granit RZ, Barbiro I, Wool A, Frenkel M, Novik A, Shuchami A, Liang Y, Carmi VD, Sabath N, Foreman R, Petrenko N, He J, Kliger Y, Levy-Barda A, Eitan R, Raban O, Sadot E, Sulimani O, Nathan AA, Adewoye H, Ferre P, Levine Z, Ophir E. Alteber Z, et al. Among authors: cojocaru g. Cancer Immunol Res. 2024 May 16. doi: 10.1158/2326-6066.CIR-23-0752. Online ahead of print. Cancer Immunol Res. 2024. PMID: 38752503
Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.
Menachem A, Alteber Z, Cojocaru G, Fridman Kfir T, Blat D, Leiderman O, Galperin M, Sever L, Cohen N, Cohen K, Granit RZ, Vols S, Frenkel M, Soffer L, Meyer K, Menachem K, Galon Tilleman H, Morein D, Borukhov I, Toporik A, Perpinial Shahor M, Tatirovsky E, Mizrachi A, Levy-Barda A, Sadot E, Strenov Y, Eitan R, Jakobson-Setton A, Yanichkin N, Ferre P, Ophir E. Menachem A, et al. Among authors: cojocaru g. Cancer Immunol Res. 2024 Apr 1:OF1-OF17. doi: 10.1158/2326-6066.CIR-23-0706. Online ahead of print. Cancer Immunol Res. 2024. PMID: 38592331
Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes.
Ligon JA, Choi W, Cojocaru G, Fu W, Hsiue EH, Oke TF, Siegel N, Fong MH, Ladle B, Pratilas CA, Morris CD, Levin A, Rhee DS, Meyer CF, Tam AJ, Blosser R, Thompson ED, Suru A, McConkey D, Housseau F, Anders R, Pardoll DM, Llosa N. Ligon JA, et al. Among authors: cojocaru g. J Immunother Cancer. 2021 May;9(5):e001772. doi: 10.1136/jitc-2020-001772. J Immunother Cancer. 2021. PMID: 34021032 Free PMC article.
COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
Hansen K, Kumar S, Logronio K, Whelan S, Qurashi S, Cheng HY, Drake A, Tang M, Wall P, Bernados D, Leung L, Ophir E, Alteber Z, Cojocaru G, Galperin M, Frenkel M, White M, Hunter J, Liang SC, Kotturi MF. Hansen K, et al. Among authors: cojocaru g. Cancer Immunol Immunother. 2021 Dec;70(12):3525-3540. doi: 10.1007/s00262-021-02921-8. Epub 2021 Apr 26. Cancer Immunol Immunother. 2021. PMID: 33903974 Free PMC article.
The Immunosuppressive Niche of Soft-Tissue Sarcomas is Sustained by Tumor-Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures.
Chen L, Oke T, Siegel N, Cojocaru G, Tam AJ, Blosser RL, Swailes J, Ligon JA, Lebid A, Morris C, Levin A, Rhee DS, Johnston FM, Greer JB, Meyer CF, Ladle BH, Thompson ED, Montgomery EA, Choi W, McConkey DJ, Anders RA, Pardoll DM, Llosa NJ. Chen L, et al. Among authors: cojocaru g. Clin Cancer Res. 2020 Aug 1;26(15):4018-4030. doi: 10.1158/1078-0432.CCR-19-3416. Epub 2020 Apr 24. Clin Cancer Res. 2020. PMID: 32332015 Free PMC article.
Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
Huetter J, Gritzan U, Gutcher I, Doecke WD, Luetke-Eversloh MV, Golfier S, Roider HG, Frisk AL, Hunter J, Pow A, Drake A, Levine Z, Levy O, Azulay M, Barbiro I, Cojocaru G, Vaknin I, Kreft B, Roese L. Huetter J, et al. Among authors: cojocaru g. Cancer Immunol Res. 2020 Jul;8(7):895-911. doi: 10.1158/2326-6066.CIR-19-0321. Epub 2020 Apr 20. Cancer Immunol Res. 2020. PMID: 32312711
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
Hecht I, Toporik A, Podojil JR, Vaknin I, Cojocaru G, Oren A, Aizman E, Liang SC, Leung L, Dicken Y, Novik A, Marbach-Bar N, Elmesmari A, Tange C, Gilmour A, McIntyre D, Kurowska-Stolarska M, McNamee K, Leitner J, Greenwald S, Dassa L, Levine Z, Steinberger P, Williams RO, Miller SD, McInnes IB, Neria E, Rotman G. Hecht I, et al. Among authors: cojocaru g. J Immunol. 2018 Mar 15;200(6):2025-2037. doi: 10.4049/jimmunol.1700325. Epub 2018 Feb 5. J Immunol. 2018. PMID: 29431694 Free PMC article.
One long and two short pumping pulses control for plasma x-ray amplifier optimization.
Cojocaru GV, Ungureanu RG, Banici RA, Ursescu D, Guilbaud O, Delmas O, Le Marec A, Neveu O, Demailly J, Pittman M, Kazamias S, Daboussi S, Cassou K, Li L, Klisnick A, Zeitoun P, Ros D. Cojocaru GV, et al. Opt Express. 2016 Jun 27;24(13):14260-70. doi: 10.1364/OE.24.014260. Opt Express. 2016. PMID: 27410582 Free article.
Gain dynamics in quickly ionized plasma for seeded operated soft x-ray lasers.
Guilbaud O, Cojocaru GV, Li L, Delmas O, Ungureanu RG, Banici RA, Kazamias S, Cassou K, Neveu O, Demailly J, Baynard E, Pittman M, Le Marec A, Klisnick A, Zeitoun P, Ursescu D, Ros D. Guilbaud O, et al. Among authors: cojocaru gv. Opt Lett. 2015 Oct 15;40(20):4775-8. doi: 10.1364/OL.40.004775. Opt Lett. 2015. PMID: 26469617
38 results