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Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis.
Cancer Cell. 2023 May 8;41(5):950-969.e6. doi: 10.1016/j.ccell.2023.04.001. Epub 2023 Apr 27.
Cancer Cell. 2023.
PMID: 37116489
Free PMC article.
Beyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition.
Codarri Deak L, Hashimoto M, Umaña P, Klein C.
Codarri Deak L, et al.
Oncoimmunology. 2023 Mar 30;12(1):2197360. doi: 10.1080/2162402X.2023.2197360. eCollection 2023.
Oncoimmunology. 2023.
PMID: 37025392
Free PMC article.
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors.
Natoli M, Hatje K, Gulati P, Junker F, Herzig P, Jiang Z, Davydov II, Germann M, Trüb M, Marbach D, Zwick A, Weber P, Seeber S, Wiese M, Lardinois D, Heinzelmann-Schwarz V, Rosenberg R, Tietze L, Mertz KD, Umaña P, Klein C, Codarri-Deak L, Kao H, Zippelius A.
Natoli M, et al. Among authors: codarri deak l.
J Immunother Cancer. 2022 Nov;10(11):e005548. doi: 10.1136/jitc-2022-005548.
J Immunother Cancer. 2022.
PMID: 36319064
Free PMC article.
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PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells.
Codarri Deak L, Nicolini V, Hashimoto M, Karagianni M, Schwalie PC, Lauener L, Varypataki EM, Richard M, Bommer E, Sam J, Joller S, Perro M, Cremasco F, Kunz L, Yanguez E, Hüsser T, Schlenker R, Mariani M, Tosevski V, Herter S, Bacac M, Waldhauer I, Colombetti S, Gueripel X, Wullschleger S, Tichet M, Hanahan D, Kissick HT, Leclair S, Freimoser-Grundschober A, Seeber S, Teichgräber V, Ahmed R, Klein C, Umaña P.
Codarri Deak L, et al.
Nature. 2022 Oct;610(7930):161-172. doi: 10.1038/s41586-022-05192-0. Epub 2022 Sep 28.
Nature. 2022.
PMID: 36171284
Free PMC article.
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A human receptor occupancy assay to measure anti-PD-1 binding in patients with prior anti-PD-1.
Junker F, Gulati P, Wessels U, Seeber S, Stubenrauch KG, Codarri-Deak L, Markert C, Klein C, Camillo Teixeira P, Kao H.
Junker F, et al. Among authors: codarri deak l.
Cytometry A. 2021 Aug;99(8):832-843. doi: 10.1002/cyto.a.24334. Epub 2021 Mar 18.
Cytometry A. 2021.
PMID: 33704890
Free PMC article.
Clinical Trial.
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