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A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer.
O'Connor R, O'Leary M, Ballot J, Collins CD, Kinsella P, Mager DE, Arnold RD, O'Driscoll L, Larkin A, Kennedy S, Fennelly D, Clynes M, Crown J. O'Connor R, et al. Among authors: clynes m. Cancer Chemother Pharmacol. 2007 Jan;59(1):79-87. doi: 10.1007/s00280-006-0240-7. Epub 2006 Apr 27. Cancer Chemother Pharmacol. 2007. PMID: 16642371 Clinical Trial.
Development of a high-performance liquid chromatographic-mass spectrometric method for the determination of cellular levels of the tyrosine kinase inhibitors lapatinib and dasatinib.
Roche S, McMahon G, Clynes M, O'Connor R. Roche S, et al. Among authors: clynes m. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Dec 1;877(31):3982-90. doi: 10.1016/j.jchromb.2009.10.008. Epub 2009 Oct 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19854117
Modulation of P-gp expression by lapatinib.
Dunne G, Breen L, Collins DM, Roche S, Clynes M, O'Connor R. Dunne G, et al. Among authors: clynes m. Invest New Drugs. 2011 Dec;29(6):1284-93. doi: 10.1007/s10637-010-9482-7. Epub 2010 Jul 6. Invest New Drugs. 2011. PMID: 20607587
Predicting cell-specific productivity from CHO gene expression.
Clarke C, Doolan P, Barron N, Meleady P, O'Sullivan F, Gammell P, Melville M, Leonard M, Clynes M. Clarke C, et al. Among authors: clynes m. J Biotechnol. 2011 Jan 20;151(2):159-65. doi: 10.1016/j.jbiotec.2010.11.016. Epub 2010 Nov 27. J Biotechnol. 2011. PMID: 21115077
322 results