Clynes D - Search Results

1

The chromatin remodeller ATRX: a repeat offender in human disease.

Clynes D, Higgs DR, Gibbons RJ. Clynes D, et al. Trends Biochem Sci. 2013 Sep;38(9):461-6. doi: 10.1016/j.tibs.2013.06.011. Epub 2013 Aug 1. Trends Biochem Sci. 2013. PMID: 23916100 Review.

2

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.

Eustermann S, Yang JC, Law MJ, Amos R, Chapman LM, Jelinska C, Garrick D, Clynes D, Gibbons RJ, Rhodes D, Higgs DR, Neuhaus D. Eustermann S, et al. Among authors: clynes d. Nat Struct Mol Biol. 2011 Jun 12;18(7):777-82. doi: 10.1038/nsmb.2070. Nat Struct Mol Biol. 2011. PMID: 21666677

3

ATRX and the replication of structured DNA.

Clynes D, Gibbons RJ. Clynes D, et al. Curr Opin Genet Dev. 2013 Jun;23(3):289-94. doi: 10.1016/j.gde.2013.01.005. Epub 2013 Feb 28. Curr Opin Genet Dev. 2013. PMID: 23453691 Review.

4

ATRX dysfunction induces replication defects in primary mouse cells.

Clynes D, Jelinska C, Xella B, Ayyub H, Taylor S, Mitson M, Bachrati CZ, Higgs DR, Gibbons RJ. Clynes D, et al. PLoS One. 2014 Mar 20;9(3):e92915. doi: 10.1371/journal.pone.0092915. eCollection 2014. PLoS One. 2014. PMID: 24651726 Free PMC article.

5

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.

Chen E, Ahn JS, Massie CE, Clynes D, Godfrey AL, Li J, Park HJ, Nangalia J, Silber Y, Mullally A, Gibbons RJ, Green AR. Chen E, et al. Among authors: clynes d. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15190-5. doi: 10.1073/pnas.1401873111. Epub 2014 Oct 6. Proc Natl Acad Sci U S A. 2014. PMID: 25288776 Free PMC article.

6

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.

Clynes D, Jelinska C, Xella B, Ayyub H, Scott C, Mitson M, Taylor S, Higgs DR, Gibbons RJ. Clynes D, et al. Nat Commun. 2015 Jul 6;6:7538. doi: 10.1038/ncomms8538. Nat Commun. 2015. PMID: 26143912 Free PMC article.

7

The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats.

Nguyen DT, Voon HPJ, Xella B, Scott C, Clynes D, Babbs C, Ayyub H, Kerry J, Sharpe JA, Sloane-Stanley JA, Butler S, Fisher CA, Gray NE, Jenuwein T, Higgs DR, Gibbons RJ. Nguyen DT, et al. Among authors: clynes d. EMBO Rep. 2017 Jun;18(6):914-928. doi: 10.15252/embr.201643078. Epub 2017 May 9. EMBO Rep. 2017. PMID: 28487353 Free PMC article.

8

Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair.

Kent T, Clynes D. Kent T, et al. Among authors: clynes d. Genes (Basel). 2021 Oct 29;12(11):1734. doi: 10.3390/genes12111734. Genes (Basel). 2021. PMID: 34828344 Free PMC article. Review.

9

Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA.

Rose AM, Goncalves T, Cunniffe S, Geiller HEB, Kent T, Shepherd S, Ratnaweera M, O'Sullivan RJ, Gibbons RJ, Clynes D. Rose AM, et al. Among authors: clynes d. Nucleic Acids Res. 2023 Jul 21;51(13):6509-6527. doi: 10.1093/nar/gkad150. Nucleic Acids Res. 2023. PMID: 36940725 Free PMC article.

10

Alternative Lengthening of Telomeres in Pediatric Cancer: Mechanisms to Therapies.

Kent T, Gracias D, Shepherd S, Clynes D. Kent T, et al. Among authors: clynes d. Front Oncol. 2020 Jan 21;9:1518. doi: 10.3389/fonc.2019.01518. eCollection 2019. Front Oncol. 2020. PMID: 32039009 Free PMC article. Review.

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