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Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL.
Largeot A, Klapp V, Viry E, Gonder S, Fernandez Botana I, Blomme A, Benzarti M, Pierson S, Duculty C, Marttila P, Wierz M, Gargiulo E, Pagano G, An N, El Hachem N, Perez Hernandez D, Chakraborty S, Ysebaert L, François JH, Cortez Clemente S, Berchem G, Efremov DG, Dittmar G, Szpakowska M, Chevigné A, Nazarov PV, Helleday T, Close P, Meiser J, Stamatopoulos B, Désaubry L, Paggetti J, Moussay E. Largeot A, et al. Among authors: close p. Blood. 2023 Jun 29;141(26):3166-3183. doi: 10.1182/blood.2022017839. Blood. 2023. PMID: 37084385 Free PMC article.
THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer.
Blomme A, Peter C, Mui E, Rodriguez Blanco G, An N, Mason LM, Jamieson LE, McGregor GH, Lilla S, Ntala C, Patel R, Thiry M, Kung SHY, Leclercq M, Ford CA, Rushworth LK, McGarry DJ, Mason S, Repiscak P, Nixon C, Salji MJ, Markert E, MacKay GM, Kamphorst JJ, Graham D, Faulds K, Fazli L, Gleave ME, Avezov E, Edwards J, Yin H, Sumpton D, Blyth K, Close P, Murphy DJ, Zanivan S, Leung HY. Blomme A, et al. Among authors: close p. EMBO Mol Med. 2022 Mar 7;14(3):e14764. doi: 10.15252/emmm.202114764. Epub 2022 Jan 11. EMBO Mol Med. 2022. PMID: 35014179 Free PMC article.
Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate.
Rapino F, Zhou Z, Roncero Sanchez AM, Joiret M, Seca C, El Hachem N, Valenti G, Latini S, Shostak K, Geris L, Li P, Huang G, Mazzucchelli G, Baiwir D, Desmet CJ, Chariot A, Georges M, Close P. Rapino F, et al. Among authors: close p. Nat Commun. 2021 Apr 15;12(1):2170. doi: 10.1038/s41467-021-22254-5. Nat Commun. 2021. PMID: 33859181 Free PMC article.
Correction to: ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity.
Cheli Y, Tulic MK, El Hachem N, Nottet N, Jacquel A, Gesson M, Strub T, Bille K, Picard-Gauci A, Montaudié H, Beranger GE, Passeron T, Close P, Bertolotto C, Ballotti R. Cheli Y, et al. Among authors: close p. Mol Cancer. 2021 Jan 27;20(1):21. doi: 10.1186/s12943-021-01319-5. Mol Cancer. 2021. PMID: 33504341 Free PMC article. No abstract available.
Codon-specific translation reprogramming promotes resistance to targeted therapy.
Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak K, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Büttner R, Marine JC, Chariot A, Close P. Rapino F, et al. Among authors: close p. Nature. 2018 Jun;558(7711):605-609. doi: 10.1038/s41586-018-0243-7. Epub 2018 Jun 20. Nature. 2018. PMID: 29925953
The E3 ligase COP1 promotes ERα signaling and suppresses EMT in breast cancer.
Tang SC, Lion Q, Peulen O, Chariot P, Lavergne A, Mayer A, Fuster PA, Close P, Klein S, Florin A, Büttner R, Nemazanyy I, Shostak K, Chariot A. Tang SC, et al. Among authors: close p. Oncogene. 2022 Jan;41(2):173-190. doi: 10.1038/s41388-021-02038-3. Epub 2021 Oct 29. Oncogene. 2022. PMID: 34716429
156 results