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Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
J Med Chem. 2023 Sep 28;66(18):13205-13246. doi: 10.1021/acs.jmedchem.3c01173. Epub 2023 Sep 15.
J Med Chem. 2023.
PMID: 37712656
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.
Van de Poël A, Toledo-Sherman L, Breccia P, Cachope R, Bate JR, Angulo-Herrera I, Wishart G, Matthews KL, Martin SL, Peacock M, Barnard A, Cox HC, Jones G, McAllister G, Vater H, Esmieu W, Clissold C, Lamers M, Leonard P, Jarvis RE, Blackaby W, Eznarriaga M, Lazari O, Yates D, Rose M, Jang SW, Muñoz-Sanjuan I, Dominguez C.
Van de Poël A, et al. Among authors: clissold c.
J Med Chem. 2021 Apr 22;64(8):5018-5036. doi: 10.1021/acs.jmedchem.1c00114. Epub 2021 Mar 30.
J Med Chem. 2021.
PMID: 33783225
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Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.
Macabuag N, Esmieu W, Breccia P, Jarvis R, Blackaby W, Lazari O, Urbonas L, Eznarriaga M, Williams R, Strijbosch A, Van de Bospoort R, Matthews K, Clissold C, Ladduwahetty T, Vater H, Heaphy P, Stafford DG, Wang HJ, Mangette JE, McAllister G, Beaumont V, Vogt TF, Wilkinson HA, Doherty EM, Dominguez C.
Macabuag N, et al. Among authors: clissold c.
J Med Chem. 2022 Sep 22;65(18):12445-12459. doi: 10.1021/acs.jmedchem.2c01149. Epub 2022 Sep 13.
J Med Chem. 2022.
PMID: 36098485
Free PMC article.
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Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
Down K, Amour A, Anderson NA, Barton N, Campos S, Cannons EP, Clissold C, Convery MA, Coward JJ, Doyle K, Duempelfeld B, Edwards CD, Goldsmith MD, Krause J, Mallett DN, McGonagle GA, Patel VK, Rowedder J, Rowland P, Sharpe A, Sriskantharajah S, Thomas DA, Thomson DW, Uddin S, Hamblin JN, Hessel EM.
Down K, et al. Among authors: clissold c.
J Med Chem. 2021 Sep 23;64(18):13780-13792. doi: 10.1021/acs.jmedchem.1c01102. Epub 2021 Sep 11.
J Med Chem. 2021.
PMID: 34510892
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Early identification of a ward-based outbreak of Clostridioides difficile using prospective multilocus sequence type-based Oxford Nanopore genomic surveillance.
Bloomfield M, Hutton S, Burton M, Tarring C, Velasco C, Clissold C, Balm M, Kelly M, Macartney-Coxson D, White R.
Bloomfield M, et al. Among authors: clissold c.
Infect Control Hosp Epidemiol. 2024 May 6:1-7. doi: 10.1017/ice.2024.77. Online ahead of print.
Infect Control Hosp Epidemiol. 2024.
PMID: 38706217
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Genetic Engineering of Streptomyces coelicolor A3(2) for the Enantioselective Reduction of Unnatural beta-Keto-Ester Substrates.
Anson CE, Bibb MJ, Booker-Milburn KI, Clissold C, Haley PJ, Hopwood DA, Ichinose K, Revill WP, Stephenson GR, Surti CM.
Anson CE, et al. Among authors: clissold c.
Angew Chem Int Ed Engl. 2000 Jan;39(1):224-227.
Angew Chem Int Ed Engl. 2000.
PMID: 10649383
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