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Human gut bacteria produce ΤΗ17-modulating bile acid metabolites.
Paik D, Yao L, Zhang Y, Bae S, D'Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, Huttenhower C, Huh JR, Devlin AS. Paik D, et al. Among authors: clish cb. Nature. 2022 Mar;603(7903):907-912. doi: 10.1038/s41586-022-04480-z. Epub 2022 Mar 16. Nature. 2022. PMID: 35296854 Free PMC article.
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. Tannahill GM, et al. Nature. 2013 Apr 11;496(7444):238-42. doi: 10.1038/nature11986. Epub 2013 Mar 24. Nature. 2013. PMID: 23535595 Free PMC article.
The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.
Kostic AD, Gevers D, Siljander H, Vatanen T, Hyötyläinen T, Hämäläinen AM, Peet A, Tillmann V, Pöhö P, Mattila I, Lähdesmäki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Orešič M, Huttenhower C, Knip M; DIABIMMUNE Study Group; Xavier RJ. Kostic AD, et al. Among authors: clish cb. Cell Host Microbe. 2015 Feb 11;17(2):260-73. doi: 10.1016/j.chom.2015.01.001. Epub 2015 Feb 5. Cell Host Microbe. 2015. PMID: 25662751 Free PMC article.
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.
Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Rothhammer V, et al. Among authors: clish cb. Nat Med. 2016 Jun;22(6):586-97. doi: 10.1038/nm.4106. Epub 2016 May 9. Nat Med. 2016. PMID: 27158906 Free PMC article.
A role for bacterial urease in gut dysbiosis and Crohn's disease.
Ni J, Shen TD, Chen EZ, Bittinger K, Bailey A, Roggiani M, Sirota-Madi A, Friedman ES, Chau L, Lin A, Nissim I, Scott J, Lauder A, Hoffmann C, Rivas G, Albenberg L, Baldassano RN, Braun J, Xavier RJ, Clish CB, Yudkoff M, Li H, Goulian M, Bushman FD, Lewis JD, Wu GD. Ni J, et al. Among authors: clish cb. Sci Transl Med. 2017 Nov 15;9(416):eaah6888. doi: 10.1126/scitranslmed.aah6888. Sci Transl Med. 2017. PMID: 29141885 Free PMC article.
481 results