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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL. Zou Y, et al. Among authors: clish cb. Nat Commun. 2019 Apr 8;10(1):1617. doi: 10.1038/s41467-019-09277-9. Nat Commun. 2019. PMID: 30962421 Free PMC article.
Metabolite profiling identifies pathways associated with metabolic risk in humans.
Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, Palma MJ, Roberts LD, Dejam A, Souza AL, Deik AA, Magnusson M, Fox CS, O'Donnell CJ, Vasan RS, Melander O, Clish CB, Gerszten RE, Wang TJ. Cheng S, et al. Among authors: clish cb. Circulation. 2012 May 8;125(18):2222-31. doi: 10.1161/CIRCULATIONAHA.111.067827. Epub 2012 Apr 11. Circulation. 2012. PMID: 22496159 Free PMC article.
Regulation of ferroptotic cancer cell death by GPX4.
Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Yang WS, et al. Among authors: clish cb. Cell. 2014 Jan 16;156(1-2):317-331. doi: 10.1016/j.cell.2013.12.010. Cell. 2014. PMID: 24439385 Free PMC article.
Distinct metabolomic signatures are associated with longevity in humans.
Cheng S, Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, Jacques PF, Ghorbani A, Magnusson M, Souza AL, Deik AA, Pierce KA, Bullock K, O'Donnell CJ, Melander O, Clish CB, Vasan RS, Gerszten RE, Wang TJ. Cheng S, et al. Among authors: clish cb. Nat Commun. 2015 Apr 13;6:6791. doi: 10.1038/ncomms7791. Nat Commun. 2015. PMID: 25864806 Free PMC article.
481 results