Clifton IJ - Search Results

1

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates.

Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ. Brem J, et al. Among authors: clifton ij. Nat Commun. 2016 Aug 8;7:12406. doi: 10.1038/ncomms12406. Nat Commun. 2016. PMID: 27499424 Free PMC article.

2

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ. Li GB, et al. Among authors: clifton ij. Chem Commun (Camb). 2017 May 30;53(43):5806-5809. doi: 10.1039/c7cc02394d. Chem Commun (Camb). 2017. PMID: 28470248 Free PMC article.

3

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.

Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Granatino N, Schofield CJ. Clifton IJ, et al. J Inorg Biochem. 2006 Apr;100(4):644-69. doi: 10.1016/j.jinorgbio.2006.01.024. Epub 2006 Mar 2. J Inorg Biochem. 2006. PMID: 16513174 Review.

4

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ. Conejo-Garcia A, et al. Among authors: clifton ij. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6125-8. doi: 10.1016/j.bmcl.2010.08.032. Epub 2010 Aug 10. Bioorg Med Chem Lett. 2010. PMID: 20822901

5

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JRC, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, von Delft F, Oppermann U, McDonough MA, Doherty AJ, Schofield CJ. Chowdhury R, et al. Among authors: clifton ij. Nature. 2014 Jun 19;510(7505):422-426. doi: 10.1038/nature13263. Epub 2014 May 11. Nature. 2014. PMID: 24814345 Free PMC article.

6

¹³C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.

Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ. Lohans CT, et al. Among authors: clifton ij. Org Biomol Chem. 2017 Jul 19;15(28):6024-6032. doi: 10.1039/c7ob01514c. Org Biomol Chem. 2017. PMID: 28678295

7

Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.

Reinbold R, Hvinden IC, Rabe P, Herold RA, Finch A, Wood J, Morgan M, Staudt M, Clifton IJ, Armstrong FA, McCullagh JSO, Redmond J, Bardella C, Abboud MI, Schofield CJ. Reinbold R, et al. Among authors: clifton ij. Nat Commun. 2022 Aug 15;13(1):4785. doi: 10.1038/s41467-022-32436-4. Nat Commun. 2022. PMID: 35970853 Free PMC article.

8

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.

Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ. Hewitson KS, et al. Among authors: clifton ij. J Biol Chem. 2007 Feb 2;282(5):3293-301. doi: 10.1074/jbc.M608337200. Epub 2006 Nov 29. J Biol Chem. 2007. PMID: 17135241 Free article.

9

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Rose NR, et al. Among authors: clifton ij. J Med Chem. 2010 Feb 25;53(4):1810-8. doi: 10.1021/jm901680b. J Med Chem. 2010. PMID: 20088513 Free PMC article.

10

Structural studies on human 2-oxoglutarate dependent oxygenases.

McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ. McDonough MA, et al. Among authors: clifton ij. Curr Opin Struct Biol. 2010 Dec;20(6):659-72. doi: 10.1016/j.sbi.2010.08.006. Epub 2010 Sep 29. Curr Opin Struct Biol. 2010. PMID: 20888218 Review.

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