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Page 1
Identification of stem cells in small intestine and colon by marker gene Lgr5.
Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H. Barker N, et al. Among authors: clevers h. Nature. 2007 Oct 25;449(7165):1003-7. doi: 10.1038/nature06196. Epub 2007 Oct 14. Nature. 2007. PMID: 17934449
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H. Barker N, et al. Among authors: clevers h. Cell Stem Cell. 2010 Jan 8;6(1):25-36. doi: 10.1016/j.stem.2009.11.013. Cell Stem Cell. 2010. PMID: 20085740 Free article.
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Sato T, et al. Among authors: clevers h. Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28. Nature. 2011. PMID: 21113151 Free PMC article.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H. de Lau W, et al. Among authors: clevers h. Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337. Nature. 2011. PMID: 21727895
Isolation and in vitro expansion of human colonic stem cells.
Jung P, Sato T, Merlos-Suárez A, Barriga FM, Iglesias M, Rossell D, Auer H, Gallardo M, Blasco MA, Sancho E, Clevers H, Batlle E. Jung P, et al. Among authors: clevers h. Nat Med. 2011 Sep 4;17(10):1225-7. doi: 10.1038/nm.2470. Nat Med. 2011. PMID: 21892181
Controlled gene expression in primary Lgr5 organoid cultures.
Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H. Koo BK, et al. Among authors: clevers h. Nat Methods. 2011 Dec 4;9(1):81-3. doi: 10.1038/nmeth.1802. Nat Methods. 2011. PMID: 22138822
822 results