Clemons PA - Search Results

1

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. Lamb J, et al. Among authors: clemons pa. Science. 2006 Sep 29;313(5795):1929-35. doi: 10.1126/science.1132939. Science. 2006. PMID: 17008526

2

Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations.

Haggarty SJ, Clemons PA, Schreiber SL. Haggarty SJ, et al. Among authors: clemons pa. J Am Chem Soc. 2003 Sep 3;125(35):10543-5. doi: 10.1021/ja035413p. J Am Chem Soc. 2003. PMID: 12940736

3

Chemical genomics: probing protein function using small molecules.

Wagner BK, Haggarty SJ, Clemons PA. Wagner BK, et al. Among authors: clemons pa. Am J Pharmacogenomics. 2004;4(5):313-20. doi: 10.2165/00129785-200404050-00004. Am J Pharmacogenomics. 2004. PMID: 15462609 Review.

4

Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors.

Haggarty SJ, Clemons PA, Wong JC, Schreiber SL. Haggarty SJ, et al. Among authors: clemons pa. Comb Chem High Throughput Screen. 2004 Nov;7(7):669-76. doi: 10.2174/1386207043328319. Comb Chem High Throughput Screen. 2004. PMID: 15578929 Review.

5

SpectralNET--an application for spectral graph analysis and visualization.

Forman JJ, Clemons PA, Schreiber SL, Haggarty SJ. Forman JJ, et al. Among authors: clemons pa. BMC Bioinformatics. 2005 Oct 19;6:260. doi: 10.1186/1471-2105-6-260. BMC Bioinformatics. 2005. PMID: 16236170 Free PMC article.

6

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.

Clemons PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, Schreiber SL. Clemons PA, et al. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18787-92. doi: 10.1073/pnas.1012741107. Epub 2010 Oct 18. Proc Natl Acad Sci U S A. 2010. PMID: 20956335 Free PMC article.

7

Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes.

Shaw SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A, Schreiber SL. Shaw SY, et al. Among authors: clemons pa. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):492-7. doi: 10.1073/pnas.1016789108. Epub 2010 Dec 23. Proc Natl Acad Sci U S A. 2011. PMID: 21183721 Free PMC article.

8

Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.

Clemons PA, Wilson JA, Dančík V, Muller S, Carrinski HA, Wagner BK, Koehler AN, Schreiber SL. Clemons PA, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6817-22. doi: 10.1073/pnas.1015024108. Epub 2011 Apr 11. Proc Natl Acad Sci U S A. 2011. PMID: 21482810 Free PMC article.

9

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, Stransky N, Kryukov GV, Dancik V, Barretina J, Garraway LA, Hon CS, Munoz B, Bittker JA, Stockwell BR, Khabele D, Stern AM, Clemons PA, Shamji AF, Schreiber SL. Basu A, et al. Among authors: clemons pa. Cell. 2013 Aug 29;154(5):1151-1161. doi: 10.1016/j.cell.2013.08.003. Cell. 2013. PMID: 23993102 Free PMC article.

10

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.

Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MAS, Scadden DT, Schreiber SL, Ebert BL, Golub TR. Hartwell KA, et al. Among authors: clemons pa. Nat Chem Biol. 2013 Dec;9(12):840-848. doi: 10.1038/nchembio.1367. Epub 2013 Oct 27. Nat Chem Biol. 2013. PMID: 24161946 Free PMC article.

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