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High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs.
Knezevic L, Wachsmann TLA, Francis O, Dockree T, Bridgeman JS, Wouters A, de Wet B, Cole DK, Clement M, McLaren JE, Gostick E, Ladell K, Llewellyn-Lacey S, Price DA, van den Berg HA, Tabi Z, Sessions RB, Heemskerk MHM, Wooldridge L. Knezevic L, et al. Among authors: clement m. J Biol Chem. 2023 Aug;299(8):104981. doi: 10.1016/j.jbc.2023.104981. Epub 2023 Jun 28. J Biol Chem. 2023. PMID: 37390984 Free PMC article.
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
Wooldridge L, Clement M, Lissina A, Edwards ES, Ladell K, Ekeruche J, Hewitt RE, Laugel B, Gostick E, Cole DK, Debets R, Berrevoets C, Miles JJ, Burrows SR, Price DA, Sewell AK. Wooldridge L, et al. Among authors: clement m. J Immunol. 2010 Apr 1;184(7):3357-66. doi: 10.4049/jimmunol.0902398. Epub 2010 Feb 26. J Immunol. 2010. PMID: 20190139 Free PMC article.
CD8 controls T cell cross-reactivity.
Wooldridge L, Laugel B, Ekeruche J, Clement M, van den Berg HA, Price DA, Sewell AK. Wooldridge L, et al. Among authors: clement m. J Immunol. 2010 Oct 15;185(8):4625-32. doi: 10.4049/jimmunol.1001480. Epub 2010 Sep 15. J Immunol. 2010. PMID: 20844204 Free PMC article.
Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.
Clement M, Ladell K, Ekeruche-Makinde J, Miles JJ, Edwards ES, Dolton G, Williams T, Schauenburg AJ, Cole DK, Lauder SN, Gallimore AM, Godkin AJ, Burrows SR, Price DA, Sewell AK, Wooldridge L. Clement M, et al. J Immunol. 2011 Jul 15;187(2):654-63. doi: 10.4049/jimmunol.1003941. Epub 2011 Jun 15. J Immunol. 2011. PMID: 21677135 Free PMC article.
Escape from highly effective public CD8+ T-cell clonotypes by HIV.
Iglesias MC, Almeida JR, Fastenackels S, van Bockel DJ, Hashimoto M, Venturi V, Gostick E, Urrutia A, Wooldridge L, Clement M, Gras S, Wilmann PG, Autran B, Moris A, Rossjohn J, Davenport MP, Takiguchi M, Brander C, Douek DC, Kelleher AD, Price DA, Appay V. Iglesias MC, et al. Among authors: clement m. Blood. 2011 Aug 25;118(8):2138-49. doi: 10.1182/blood-2011-01-328781. Epub 2011 Jul 6. Blood. 2011. PMID: 21734237 Free PMC article.
A single autoimmune T cell receptor recognizes more than a million different peptides.
Wooldridge L, Ekeruche-Makinde J, van den Berg HA, Skowera A, Miles JJ, Tan MP, Dolton G, Clement M, Llewellyn-Lacey S, Price DA, Peakman M, Sewell AK. Wooldridge L, et al. Among authors: clement m. J Biol Chem. 2012 Jan 6;287(2):1168-77. doi: 10.1074/jbc.M111.289488. Epub 2011 Nov 18. J Biol Chem. 2012. PMID: 22102287 Free PMC article.
The molecular determinants of CD8 co-receptor function.
Cole DK, Laugel B, Clement M, Price DA, Wooldridge L, Sewell AK. Cole DK, et al. Among authors: clement m. Immunology. 2012 Oct;137(2):139-48. doi: 10.1111/j.1365-2567.2012.03625.x. Immunology. 2012. PMID: 22804746 Free PMC article. Review.
857 results