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TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair.
Cherief M, Xu J, Li Z, Tower RJ, Ramesh S, Qin Q, Gomez-Salazar M, Yea JH, Lee S, Negri S, Xu M, Price T, Kendal AR, Fan CM, Clemens TL, Levi B, James AW. Cherief M, et al. Among authors: clemens tl. Sci Transl Med. 2023 Dec 20;15(727):eade4619. doi: 10.1126/scitranslmed.ade4619. Epub 2023 Dec 20. Sci Transl Med. 2023. PMID: 38117901
A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth.
Dirckx N, Zhang Q, Chu EY, Tower RJ, Li Z, Guo S, Yuan S, Khare PA, Zhang C, Verardo A, Alejandro LO, Park A, Faugere MC, Helfand SL, Somerman MJ, Riddle RC, de Cabo R, Le A, Schmidt-Rohr K, Clemens TL. Dirckx N, et al. Among authors: clemens tl. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212178119. doi: 10.1073/pnas.2212178119. Epub 2022 Nov 2. Proc Natl Acad Sci U S A. 2022. PMID: 36322718 Free PMC article.
TrkA+ Neurons Induce Pathologic Regeneration After Soft Tissue Trauma.
Cherief M, Negri S, Qin Q, Pagani CA, Lee S, Yang YP, Clemens TL, Levi B, James AW. Cherief M, et al. Among authors: clemens tl. Stem Cells Transl Med. 2022 Nov 18;11(11):1165-1176. doi: 10.1093/stcltm/szac073. Stem Cells Transl Med. 2022. PMID: 36222619 Free PMC article.
NGF-p75 signaling coordinates skeletal cell migration during bone repair.
Xu J, Li Z, Tower RJ, Negri S, Wang Y, Meyers CA, Sono T, Qin Q, Lu A, Xing X, McCarthy EF, Clemens TL, James AW. Xu J, et al. Among authors: clemens tl. Sci Adv. 2022 Mar 18;8(11):eabl5716. doi: 10.1126/sciadv.abl5716. Epub 2022 Mar 18. Sci Adv. 2022. PMID: 35302859 Free PMC article.
Spatial transcriptomics reveals a role for sensory nerves in preserving cranial suture patency through modulation of BMP/TGF-β signaling.
Tower RJ, Li Z, Cheng YH, Wang XW, Rajbhandari L, Zhang Q, Negri S, Uytingco CR, Venkatesan A, Zhou FQ, Cahan P, James AW, Clemens TL. Tower RJ, et al. Among authors: clemens tl. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2103087118. doi: 10.1073/pnas.2103087118. Proc Natl Acad Sci U S A. 2021. PMID: 34663698 Free PMC article.
NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma.
Lee S, Hwang C, Marini S, Tower RJ, Qin Q, Negri S, Pagani CA, Sun Y, Stepien DM, Sorkin M, Kubiak CA, Visser ND, Meyers CA, Wang Y, Rasheed HA, Xu J, Miller S, Huber AK, Minichiello L, Cederna PS, Kemp SWP, Clemens TL, James AW, Levi B. Lee S, et al. Among authors: clemens tl. Nat Commun. 2021 Aug 16;12(1):4939. doi: 10.1038/s41467-021-25143-z. Nat Commun. 2021. PMID: 34400627 Free PMC article.
198 results