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Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: Quantification using isotope dilution mass spectrometry.
Yutuc E, Dickson AL, Pacciarini M, Griffiths L, Baker PRS, Connell L, Öhman A, Forsgren L, Trupp M, Vilarinho S, Khalil Y, Clayton PT, Sari S, Dalgic B, Höflinger P, Schöls L, Griffiths WJ, Wang Y. Yutuc E, et al. Among authors: clayton pt. Anal Chim Acta. 2021 Apr 15;1154:338259. doi: 10.1016/j.aca.2021.338259. Epub 2021 Feb 4. Anal Chim Acta. 2021. PMID: 33736801 Free PMC article.
Cholestenoic acids regulate motor neuron survival via liver X receptors.
Theofilopoulos S, Griffiths WJ, Crick PJ, Yang S, Meljon A, Ogundare M, Kitambi SS, Lockhart A, Tuschl K, Clayton PT, Morris AA, Martinez A, Reddy MA, Martinuzzi A, Bassi MT, Honda A, Mizuochi T, Kimura A, Nittono H, De Michele G, Carbone R, Criscuolo C, Yau JL, Seckl JR, Schüle R, Schöls L, Sailer AW, Kuhle J, Fraidakis MJ, Gustafsson JÅ, Steffensen KR, Björkhem I, Ernfors P, Sjövall J, Arenas E, Wang Y. Theofilopoulos S, et al. Among authors: clayton pt. J Clin Invest. 2014 Nov;124(11):4829-42. doi: 10.1172/JCI68506. Epub 2014 Oct 1. J Clin Invest. 2014. PMID: 25271621 Free PMC article.
Quantitative charge-tags for sterol and oxysterol analysis.
Crick PJ, William Bentley T, Abdel-Khalik J, Matthews I, Clayton PT, Morris AA, Bigger BW, Zerbinati C, Tritapepe L, Iuliano L, Wang Y, Griffiths WJ. Crick PJ, et al. Among authors: clayton pt. Clin Chem. 2015 Feb;61(2):400-11. doi: 10.1373/clinchem.2014.231332. Epub 2014 Dec 15. Clin Chem. 2015. PMID: 25512642
Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients.
Griffiths WJ, Abdel-Khalik J, Crick PJ, Ogundare M, Shackleton CH, Tuschl K, Kwok MK, Bigger BW, Morris AA, Honda A, Xu L, Porter NA, Björkhem I, Clayton PT, Wang Y. Griffiths WJ, et al. Among authors: clayton pt. J Steroid Biochem Mol Biol. 2017 May;169:77-87. doi: 10.1016/j.jsbmb.2016.03.018. Epub 2016 Mar 11. J Steroid Biochem Mol Biol. 2017. PMID: 26976653 Free PMC article.
ACOX2 deficiency: A disorder of bile acid synthesis with transaminase elevation, liver fibrosis, ataxia, and cognitive impairment.
Vilarinho S, Sari S, Mazzacuva F, Bilgüvar K, Esendagli-Yilmaz G, Jain D, Akyol G, Dalgiç B, Günel M, Clayton PT, Lifton RP. Vilarinho S, et al. Among authors: clayton pt. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11289-11293. doi: 10.1073/pnas.1613228113. Epub 2016 Sep 19. Proc Natl Acad Sci U S A. 2016. PMID: 27647924 Free PMC article.
Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates.
Abdel-Khalik J, Hearn T, Dickson AL, Crick PJ, Yutuc E, Austin-Muttitt K, Bigger BW, Morris AA, Shackleton CH, Clayton PT, Iida T, Sircar R, Rohatgi R, Marschall HU, Sjövall J, Björkhem I, Mullins JGL, Griffiths WJ, Wang Y. Abdel-Khalik J, et al. Among authors: clayton pt. J Steroid Biochem Mol Biol. 2021 Feb;206:105794. doi: 10.1016/j.jsbmb.2020.105794. Epub 2020 Nov 24. J Steroid Biochem Mol Biol. 2021. PMID: 33246156 Free PMC article.
Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation.
Khalil Y, Carrino S, Lin F, Ferlin A, Lad HV, Mazzacuva F, Falcone S, Rivers N, Banks G, Concas D, Aguilar C, Haynes AR, Blease A, Nicol T, Al-Shawi R, Heywood W, Potter P, Mills K, Gale DP, Clayton PT. Khalil Y, et al. Among authors: clayton pt. Int J Mol Sci. 2022 Jan 17;23(2):987. doi: 10.3390/ijms23020987. Int J Mol Sci. 2022. PMID: 35055171 Free PMC article.
249 results