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Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency.
Dahal S, Clayton K, Been T, Fernet-Brochu R, Ocando AV, Balachandran A, Poirier M, Maldonado RK, Shkreta L, Boligan KF, Guvenc F, Rahman F, Branch D, Bell B, Chabot B, Gray-Owen SD, Parent LJ, Cochrane A. Dahal S, et al. Among authors: clayton k. Retrovirology. 2022 Aug 19;19(1):18. doi: 10.1186/s12977-022-00605-4. Retrovirology. 2022. PMID: 35986377 Free PMC article.
On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine.
Dahal S, Clayton K, Cabral T, Cheng R, Jahanshahi S, Ahmed C, Koirala A, Villasmil Ocando A, Malty R, Been T, Hernandez J, Mangos M, Shen D, Babu M, Calarco J, Chabot B, Attisano L, Houry WA, Cochrane A. Dahal S, et al. Among authors: clayton k. J Virol. 2023 Oct 31;97(10):e0039623. doi: 10.1128/jvi.00396-23. Epub 2023 Sep 14. J Virol. 2023. PMID: 37706687 Free PMC article.
Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA. Mujib S, et al. Among authors: clayton k. J Immunol. 2012 Apr 15;188(8):3745-56. doi: 10.4049/jimmunol.1102609. Epub 2012 Mar 14. J Immunol. 2012. PMID: 22422881
Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.
Sakhdari A, Mujib S, Vali B, Yue FY, MacParland S, Clayton K, Jones RB, Liu J, Lee EY, Benko E, Kovacs C, Gommerman J, Kaul R, Ostrowski MA. Sakhdari A, et al. Among authors: clayton k. PLoS One. 2012;7(7):e40146. doi: 10.1371/journal.pone.0040146. Epub 2012 Jul 5. PLoS One. 2012. PMID: 22792231 Free PMC article.
Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression.
Clayton KL, Douglas-Vail MB, Nur-ur Rahman AK, Medcalf KE, Xie IY, Chew GM, Tandon R, Lanteri MC, Norris PJ, Deeks SG, Ndhlovu LC, Ostrowski MA. Clayton KL, et al. J Virol. 2015 Apr;89(7):3723-36. doi: 10.1128/JVI.00006-15. Epub 2015 Jan 21. J Virol. 2015. PMID: 25609823 Free PMC article.
HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.
Jones RB, Garrison KE, Mujib S, Mihajlovic V, Aidarus N, Hunter DV, Martin E, John VM, Zhan W, Faruk NF, Gyenes G, Sheppard NC, Priumboom-Brees IM, Goodwin DA, Chen L, Rieger M, Muscat-King S, Loudon PT, Stanley C, Holditch SJ, Wong JC, Clayton K, Duan E, Song H, Xu Y, SenGupta D, Tandon R, Sacha JB, Brockman MA, Benko E, Kovacs C, Nixon DF, Ostrowski MA. Jones RB, et al. Among authors: clayton k. J Clin Invest. 2012 Dec;122(12):4473-89. doi: 10.1172/JCI64560. Epub 2012 Nov 12. J Clin Invest. 2012. PMID: 23143309 Free PMC article.
152 results