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Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation.
Clark LJ, Krieger J, White AD, Bondarenko V, Lei S, Fang F, Lee JY, Doruker P, Böttke T, Jean-Alphonse F, Tang P, Gardella TJ, Xiao K, Sutkeviciute I, Coin I, Bahar I, Vilardaga JP. Clark LJ, et al. Nat Chem Biol. 2020 Oct;16(10):1096-1104. doi: 10.1038/s41589-020-0567-0. Epub 2020 Jul 6. Nat Chem Biol. 2020. PMID: 32632293 Free PMC article.
Transmission electron microscopy for the evaluation and optimization of crystal growth.
Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Nagarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE, Calero G. Stevenson HP, et al. Acta Crystallogr D Struct Biol. 2016 May;72(Pt 5):603-15. doi: 10.1107/S2059798316001546. Epub 2016 Apr 26. Acta Crystallogr D Struct Biol. 2016. PMID: 27139624 Free PMC article.
Ca2+ allostery in PTH-receptor signaling.
White AD, Fang F, Jean-Alphonse FG, Clark LJ, An HJ, Liu H, Zhao Y, Reynolds SL, Lee S, Xiao K, Sutkeviciute I, Vilardaga JP. White AD, et al. Among authors: clark lj. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3294-3299. doi: 10.1073/pnas.1814670116. Epub 2019 Feb 4. Proc Natl Acad Sci U S A. 2019. PMID: 30718391 Free PMC article.
Structure and dynamics of the active human parathyroid hormone receptor-1.
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y. Zhao LH, et al. Among authors: clark lj. Science. 2019 Apr 12;364(6436):148-153. doi: 10.1126/science.aav7942. Science. 2019. PMID: 30975883 Free PMC article.
PTH/PTHrP Receptor Signaling, Allostery, and Structures.
Sutkeviciute I, Clark LJ, White AD, Gardella TJ, Vilardaga JP. Sutkeviciute I, et al. Among authors: clark lj. Trends Endocrinol Metab. 2019 Nov;30(11):860-874. doi: 10.1016/j.tem.2019.07.011. Trends Endocrinol Metab. 2019. PMID: 31699241 Free PMC article. Review.
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.
White AD, Peña KA, Clark LJ, Maria CS, Liu S, Jean-Alphonse FG, Lee JY, Lei S, Cheng Z, Tu CL, Fang F, Szeto N, Gardella TJ, Xiao K, Gellman SH, Bahar I, Sutkeviciute I, Chang W, Vilardaga JP. White AD, et al. Among authors: clark lj. Sci Signal. 2021 Oct 5;14(703):eabc5944. doi: 10.1126/scisignal.abc5944. Epub 2021 Oct 5. Sci Signal. 2021. PMID: 34609896 Free PMC article.
Precise druggability of the PTH type 1 receptor.
Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP. Sutkeviciute I, et al. Among authors: clark lj. Nat Chem Biol. 2022 Mar;18(3):272-280. doi: 10.1038/s41589-021-00929-w. Epub 2021 Dec 23. Nat Chem Biol. 2022. PMID: 34949836 Free PMC article.
84 results