Clark JK - Search Results

1

A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host.

Bom A, Bradley M, Cameron K, Clark JK, Van Egmond J, Feilden H, MacLean EJ, Muir AW, Palin R, Rees DC, Zhang MQ. Bom A, et al. Among authors: clark jk. Angew Chem Int Ed Engl. 2002 Jan 18;41(2):266-70. doi: 10.1002/1521-3773(20020118)41:2<265::aid-anie265>3.0.co;2-q. Angew Chem Int Ed Engl. 2002. PMID: 12491405 No abstract available.

2

Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships.

Adam JM, Bennett DJ, Bom A, Clark JK, Feilden H, Hutchinson EJ, Palin R, Prosser A, Rees DC, Rosair GM, Stevenson D, Tarver GJ, Zhang MQ. Adam JM, et al. Among authors: clark jk. J Med Chem. 2002 Apr 25;45(9):1806-16. doi: 10.1021/jm011107f. J Med Chem. 2002. PMID: 11960492

3

New approaches to reversal of neuromuscular block.

Bom A, Clark JK, Palin R. Bom A, et al. Among authors: clark jk. Curr Opin Drug Discov Devel. 2002 Sep;5(5):793-800. Curr Opin Drug Discov Devel. 2002. PMID: 12630300 Review.

4

Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.

Clark JK, Cowley P, Muir AW, Palin R, Pow E, Prosser AB, Taylor R, Zhang MQ. Clark JK, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2565-8. doi: 10.1016/s0960-894x(02)00482-1. Bioorg Med Chem Lett. 2002. PMID: 12182861

5

Novel piperidinium and pyridinium agents as water-soluble acetylcholinesterase inhibitors for the reversal of neuromuscular blockade.

Palin R, Clark JK, Cowley P, Muir AW, Pow E, Prosser AB, Taylor R, Zhang MQ. Palin R, et al. Among authors: clark jk. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2569-72. doi: 10.1016/s0960-894x(02)00483-3. Bioorg Med Chem Lett. 2002. PMID: 12182862

6

Non-depolarizing neuromuscular blocking activity of bisquaternary amino di- and tripeptide derivatives.

Booij LH, van der Broek LA, Caulfield W, Dommerholt-Caris BM, Clark JK, van Egmond J, McGuire R, Muir AW, Ottenheijm HC, Rees DC. Booij LH, et al. Among authors: clark jk. J Med Chem. 2000 Dec 14;43(25):4822-33. doi: 10.1021/jm0010062. J Med Chem. 2000. PMID: 11123992

7

Modified gamma-cyclodextrins and their rocuronium complexes.

Cameron KS, Clark JK, Cooper A, Fielding L, Palin R, Rutherford SJ, Zhang MQ. Cameron KS, et al. Among authors: clark jk. Org Lett. 2002 Oct 3;4(20):3403-6. doi: 10.1021/ol020126w. Org Lett. 2002. PMID: 12323029

8

Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties.

Palin R, Bom A, Clark JK, Evans L, Feilden H, Houghton AK, Jones PS, Montgomery B, Weston MA, Wishart G. Palin R, et al. Among authors: clark jk. Bioorg Med Chem. 2007 Feb 15;15(4):1828-47. doi: 10.1016/j.bmc.2006.11.030. Epub 2006 Nov 19. Bioorg Med Chem. 2007. PMID: 17166723

9

Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.

Palin R, Barn DR, Clark JK, Cottney JE, Cowley PM, Crockatt M, Evans L, Feilden H, Goodwin RR, Griekspoor F, Grove SJ, Houghton AK, Jones PS, Morphy RJ, Smith AR, Sundaram H, Vrolijk D, Weston MA, Wishart G, Wren P. Palin R, et al. Among authors: clark jk. Bioorg Med Chem Lett. 2005 Feb 1;15(3):589-93. doi: 10.1016/j.bmcl.2004.11.049. Bioorg Med Chem Lett. 2005. PMID: 15664818

10

Structure-activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties.

Palin R, Clark JK, Evans L, Houghton AK, Jones PS, Prosser A, Wishart G, Yoshiizumi K. Palin R, et al. Among authors: clark jk. Bioorg Med Chem. 2008 Mar 15;16(6):2829-51. doi: 10.1016/j.bmc.2008.01.005. Epub 2008 Jan 10. Bioorg Med Chem. 2008. PMID: 18249547

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