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A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells.
Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Frueh F, Hurst BL, Wang H, Kocurek KI, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. Mellott DM, et al. Among authors: clark ae. bioRxiv [Preprint]. 2020 Oct 30:2020.10.23.347534. doi: 10.1101/2020.10.23.347534. bioRxiv. 2020. PMID: 33140046 Free PMC article. Updated. Preprint.
Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors.
Mor M, Werbner M, Alter J, Safra M, Chomsky E, Hada-Neeman S, Polonsky K, Nowell CJ, Clark AE, Roitburd-Berman A, Shalom NB, Navon M, Rafael D, Sharim H, Kiner E, Griffis E, Gershoni JM, Kobiler O, Leibel SL, Zimhony O, Carlin AF, Yaari G, Dassau M, Gal-Tanamy M, Hagin D, Croker BA, Freund NT. Mor M, et al. Among authors: clark ae. bioRxiv [Preprint]. 2020 Oct 6:2020.10.06.323634. doi: 10.1101/2020.10.06.323634. bioRxiv. 2020. PMID: 33052341 Free PMC article. Updated. Preprint.
A Human 3D neural assembloid model for SARS-CoV-2 infection.
Wang L, Sievert D, Clark AE, Federman H, Gastfriend BD, Shusta E, Palecek SP, Carlin AF, Gleeson J. Wang L, et al. Among authors: clark ae. bioRxiv [Preprint]. 2021 Feb 9:2021.02.09.430349. doi: 10.1101/2021.02.09.430349. bioRxiv. 2021. PMID: 33594369 Free PMC article. Updated. Preprint.
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Yoon MC, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Hook V, Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. Mellott DM, et al. Among authors: clark ae. ACS Chem Biol. 2021 Apr 16;16(4):642-650. doi: 10.1021/acschembio.0c00875. Epub 2021 Mar 31. ACS Chem Biol. 2021. PMID: 33787221
Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors.
Huff S, Kummetha IR, Tiwari SK, Huante MB, Clark AE, Wang S, Bray W, Smith D, Carlin AF, Endsley M, Rana TM. Huff S, et al. Among authors: clark ae. J Med Chem. 2022 Feb 24;65(4):2866-2879. doi: 10.1021/acs.jmedchem.1c00566. Epub 2021 Sep 27. J Med Chem. 2022. PMID: 34570513 Free PMC article.
A Dual-Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain-like Proteases of SARS-CoV-2-Infected Cells for Accurate Detection and Rapid Inhibitor Screening.
Cheng Y, Borum RM, Clark AE, Jin Z, Moore C, Fajtová P, O'Donoghue AJ, Carlin AF, Jokerst JV. Cheng Y, et al. Among authors: clark ae. Angew Chem Int Ed Engl. 2022 Feb 21;61(9):e202113617. doi: 10.1002/anie.202113617. Epub 2022 Jan 14. Angew Chem Int Ed Engl. 2022. PMID: 34889013 Free PMC article.
Protease-Responsive Peptide-Conjugated Mitochondrial-Targeting AIEgens for Selective Imaging and Inhibition of SARS-CoV-2-Infected Cells.
Cheng Y, Clark AE, Zhou J, He T, Li Y, Borum RM, Creyer MN, Xu M, Jin Z, Zhou J, Yim W, Wu Z, Fajtová P, O'Donoghue AJ, Carlin AF, Jokerst JV. Cheng Y, et al. Among authors: clark ae. ACS Nano. 2022 Aug 23;16(8):12305-12317. doi: 10.1021/acsnano.2c03219. Epub 2022 Jul 25. ACS Nano. 2022. PMID: 35878004 Free PMC article.
A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease.
Xu M, Zhou J, Cheng Y, Jin Z, Clark AE, He T, Yim W, Li Y, Chang YC, Wu Z, Fajtová P, O'Donoghue AJ, Carlin AF, Todd MD, Jokerst JV. Xu M, et al. Among authors: clark ae. Anal Chem. 2022 Aug 30;94(34):11728-11733. doi: 10.1021/acs.analchem.2c02381. Epub 2022 Aug 16. Anal Chem. 2022. PMID: 35973073 Free PMC article.
366 results