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In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus.
Menzies SK, Clare RH, Xie C, Westhorpe A, Hall SR, Edge RJ, Alsolaiss J, Crittenden E, Marriott AE, Harrison RA, Kool J, Casewell NR. Menzies SK, et al. Among authors: clare rh. Toxicon X. 2022 Mar 18;14:100118. doi: 10.1016/j.toxcx.2022.100118. eCollection 2022 Jun. Toxicon X. 2022. PMID: 35321116 Free PMC article.
African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.
Solano G, Cunningham S, Edge RJ, Duran G, Sanchez A, Villalta M, Clare RH, Wilkinson MC, Marriott AE, Abada C, Menzies SK, Keen M, Lalloo DG, Stienstra Y, Abouyannis M, Casewell NR, León G, Ainsworth S. Solano G, et al. Among authors: clare rh. BMJ Glob Health. 2024 Mar 13;9(3):e014813. doi: 10.1136/bmjgh-2023-014813. BMJ Glob Health. 2024. PMID: 38485142 Free PMC article.
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
Clare RH, Bardelle C, Harper P, Hong WD, Börjesson U, Johnston KL, Collier M, Myhill L, Cassidy A, Plant D, Plant H, Clark R, Cook DAN, Steven A, Archer J, McGillan P, Charoensutthivarakul S, Bibby J, Sharma R, Nixon GL, Slatko BE, Cantin L, Wu B, Turner J, Ford L, Rich K, Wigglesworth M, Berry NG, O'Neill PM, Taylor MJ, Ward SA. Clare RH, et al. Nat Commun. 2019 Jan 2;10(1):11. doi: 10.1038/s41467-018-07826-2. Nat Commun. 2019. PMID: 30602718 Free PMC article.
Development of a High-Throughput Cytometric Screen to Identify Anti- Wolbachia Compounds: The Power of Public-Private Partnership.
Clare RH, Clark R, Bardelle C, Harper P, Collier M, Johnston KL, Plant H, Plant D, McCall E, Slatko BE, Cantin L, Wu B, Ford L, Murray D, Rich K, Wigglesworth M, Taylor MJ, Ward SA. Clare RH, et al. SLAS Discov. 2019 Jun;24(5):537-547. doi: 10.1177/2472555219838341. Epub 2019 Apr 8. SLAS Discov. 2019. PMID: 30958712 Free PMC article.
20 results