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Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.
Xu J, Grosslight S, Mack KA, Nguyen SC, Clagg K, Lim NK, Timmerman JC, Shen J, White NA, Sirois LE, Han C, Zhang H, Sigman MS, Gosselin F. Xu J, et al. Among authors: clagg k. J Am Chem Soc. 2022 Nov 16;144(45):20955-20963. doi: 10.1021/jacs.2c09917. Epub 2022 Nov 3. J Am Chem Soc. 2022. PMID: 36326518
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.
Xu J, Lim NK, Timmerman JC, Shen J, Clagg K, Orcel U, Bigler R, Trachsel E, Meier R, White NA, Burkhard JA, Sirois LE, Tian Q, Angelaud R, Bachmann S, Zhang H, Gosselin F. Xu J, et al. Among authors: clagg k. Org Lett. 2023 May 19;25(19):3417-3422. doi: 10.1021/acs.orglett.3c00961. Epub 2023 May 10. Org Lett. 2023. PMID: 37162129
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
Romero FA, Murray J, Lai KW, Tsui V, Albrecht BK, An L, Beresini MH, de Leon Boenig G, Bronner SM, Chan EW, Chen KX, Chen Z, Choo EF, Clagg K, Clark K, Crawford TD, Cyr P, de Almeida Nagata D, Gascoigne KE, Grogan JL, Hatzivassiliou G, Huang W, Hunsaker TL, Kaufman S, Koenig SG, Li R, Li Y, Liang X, Liao J, Liu W, Ly J, Maher J, Masui C, Merchant M, Ran Y, Taylor AM, Wai J, Wang F, Wei X, Yu D, Zhu BY, Zhu X, Magnuson S. Romero FA, et al. Among authors: clagg k. J Med Chem. 2017 Nov 22;60(22):9162-9183. doi: 10.1021/acs.jmedchem.7b00796. Epub 2017 Sep 21. J Med Chem. 2017. PMID: 28892380
Totally Implantable IV Treprostinil Therapy in Pulmonary Hypertension Assessment of the Implantation Procedure.
Waxman AB, McElderry HT, Gomberg-Maitland M, Burke MC, Ross EL, Bersohn MM, Pangarkar SS, Tarver JH, Zwicke DL, Feldman JP, Chakinala MM, Frantz RP, Thompson GB, Torres F, Rauck RL, Clagg K, Durst L, Li P, Morris M, Southall KL, Peterson L, Bourge RC. Waxman AB, et al. Among authors: clagg k. Chest. 2017 Dec;152(6):1128-1134. doi: 10.1016/j.chest.2017.04.188. Epub 2017 Jun 3. Chest. 2017. PMID: 28583617 Clinical Trial.