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Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.
Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M, Kühnen P; Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Clément K, et al. Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. doi: 10.1016/S2213-8587(20)30364-8. Epub 2020 Oct 30. Lancet Diabetes Endocrinol. 2020. PMID: 33137293 Clinical Trial.
[Is obesity an inflammatory disease?].
Cancello R, Taleb S, Poitou C, Tordjman J, Lacasa D, Guerre-Millo M, Clément K. Cancello R, et al. Among authors: clement k. Journ Annu Diabetol Hotel Dieu. 2006:115-28. Journ Annu Diabetol Hotel Dieu. 2006. PMID: 17051855 Review. French. No abstract available.
Rare genetic forms of obesity: From gene to therapy.
Clément K, Mosbah H, Poitou C. Clément K, et al. Physiol Behav. 2020 Dec 1;227:113134. doi: 10.1016/j.physbeh.2020.113134. Epub 2020 Aug 14. Physiol Behav. 2020. PMID: 32805220
COVID-19 and its Severity in Bariatric Surgery-Operated Patients.
Bel Lassen P, Poitou C, Genser L, Marchelli F, Aron-Wisnewsky J, Ciangura C, Jacques F, Moreau P; NutriOmics investigators; Oppert JM, Clément K. Bel Lassen P, et al. Among authors: clement k. Obesity (Silver Spring). 2021 Jan;29(1):24-28. doi: 10.1002/oby.23026. Epub 2020 Dec 3. Obesity (Silver Spring). 2021. PMID: 32875723
Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use.
Le Collen L, Delemer B, Poitou C, Vaxillaire M, Toussaint B, Dechaume A, Badreddine A, Boissel M, Derhourhi M, Clément K, Petit JM, Mau-Them FT, Bruel AL, Thauvin-Robinet C, Saveanu A, Cherifi BG, Le Beyec-Le Bihan J, Froguel P, Bonnefond A. Le Collen L, et al. Among authors: clement k. Genet Med. 2023 Jul;25(7):100857. doi: 10.1016/j.gim.2023.100857. Epub 2023 Apr 21. Genet Med. 2023. PMID: 37092539
684 results