Cisar JS - Search Results

1

N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.

Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, Legenski K, Matico R, Shaffer P, Simonnet Y, Tanner A, Wang CY, Wang W, Attar R, Edwards JP, Kuduk SD. Cisar JS, et al. J Med Chem. 2022 Aug 25;65(16):11241-11256. doi: 10.1021/acs.jmedchem.2c00788. Epub 2022 Aug 4. J Med Chem. 2022. PMID: 35925768

2

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.

Cisar JS, Weber OD, Clapper JR, Blankman JL, Henry CL, Simon GM, Alexander JP, Jones TK, Ezekowitz RAB, O'Neill GP, Grice CA. Cisar JS, et al. J Med Chem. 2018 Oct 25;61(20):9062-9084. doi: 10.1021/acs.jmedchem.8b00951. Epub 2018 Aug 23. J Med Chem. 2018. PMID: 30067909

3

Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.

DeRatt LG, Pietsch EC, Cisar JS, Jacoby E, Kazmi F, Matico R, Shaffer P, Tanner A, Wang W, Attar R, Edwards JP, Kuduk SD. DeRatt LG, et al. Among authors: cisar js. ACS Med Chem Lett. 2024 Feb 7;15(3):381-387. doi: 10.1021/acsmedchemlett.3c00543. eCollection 2024 Mar 14. ACS Med Chem Lett. 2024. PMID: 38505861

4

Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis.

Struble TJ, Alvarez JC, Brown SP, Chytil M, Cisar J, DesJarlais RL, Engkvist O, Frank SA, Greve DR, Griffin DJ, Hou X, Johannes JW, Kreatsoulas C, Lahue B, Mathea M, Mogk G, Nicolaou CA, Palmer AD, Price DJ, Robinson RI, Salentin S, Xing L, Jaakkola T, Green WH, Barzilay R, Coley CW, Jensen KF. Struble TJ, et al. J Med Chem. 2020 Aug 27;63(16):8667-8682. doi: 10.1021/acs.jmedchem.9b02120. Epub 2020 Apr 14. J Med Chem. 2020. PMID: 32243158 Free PMC article.

5

Quantification of In Vivo Target Engagement Using Microfluidic Activity-Based Protein Profiling.

Reardon HT, Herbst RA, Henry CL, Herbst DM, Ngo N, Cisar JS, Weber OD, Niphakis MJ, O'Neill GP. Reardon HT, et al. Among authors: cisar js. SLAS Technol. 2019 Oct;24(5):489-498. doi: 10.1177/2472630319852303. Epub 2019 Jun 14. SLAS Technol. 2019. PMID: 31199699

6

Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.

Clapper JR, Henry CL, Niphakis MJ, Knize AM, Coppola AR, Simon GM, Ngo N, Herbst RA, Herbst DM, Reed AW, Cisar JS, Weber OD, Viader A, Alexander JP, Cunningham ML, Jones TK, Fraser IP, Grice CA, Ezekowitz RAB, O'Neill GP, Blankman JL. Clapper JR, et al. Among authors: cisar js. J Pharmacol Exp Ther. 2018 Dec;367(3):494-508. doi: 10.1124/jpet.118.252296. Epub 2018 Oct 10. J Pharmacol Exp Ther. 2018. PMID: 30305428

7

Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.

Lun S, Guo H, Adamson J, Cisar JS, Davis TD, Chavadi SS, Warren JD, Quadri LE, Tan DS, Bishai WR. Lun S, et al. Among authors: cisar js. Antimicrob Agents Chemother. 2013 Oct;57(10):5138-40. doi: 10.1128/AAC.00918-13. Epub 2013 Jul 15. Antimicrob Agents Chemother. 2013. PMID: 23856770 Free PMC article.

8

Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.

Li J, Cisar JS, Zhou CY, Vera B, Williams H, Rodríguez AD, Cravatt BF, Romo D. Li J, et al. Among authors: cisar js. Nat Chem. 2013 Jun;5(6):510-7. doi: 10.1038/nchem.1653. Epub 2013 May 19. Nat Chem. 2013. PMID: 23695633 Free PMC article.

9

Activity-based labeling of matrix metalloproteinases in living vertebrate embryos.

Keow JY, Pond ED, Cisar JS, Cravatt BF, Crawford BD. Keow JY, et al. Among authors: cisar js. PLoS One. 2012;7(8):e43434. doi: 10.1371/journal.pone.0043434. Epub 2012 Aug 28. PLoS One. 2012. PMID: 22952682 Free PMC article.

10

Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.

Cisar JS, Cravatt BF. Cisar JS, et al. J Am Chem Soc. 2012 Jun 27;134(25):10385-8. doi: 10.1021/ja304213w. Epub 2012 Jun 13. J Am Chem Soc. 2012. PMID: 22667687 Free PMC article.

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