Cirstea IC - Search Results

1

Senescence in RASopathies, a possible novel contributor to a complex pathophenoype.

Engler M, Fidan M, Nandi S, Cirstea IC. Engler M, et al. Among authors: cirstea ic. Mech Ageing Dev. 2021 Mar;194:111411. doi: 10.1016/j.mad.2020.111411. Epub 2020 Dec 9. Mech Ageing Dev. 2021. PMID: 33309600 Free article. Review.

2

Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling.

Motta M, Fidan M, Bellacchio E, Pantaleoni F, Schneider-Heieck K, Coppola S, Borck G, Salviati L, Zenker M, Cirstea IC, Tartaglia M. Motta M, et al. Among authors: cirstea ic. Hum Mol Genet. 2019 Mar 15;28(6):1007-1022. doi: 10.1093/hmg/ddy412. Hum Mol Genet. 2019. PMID: 30481304

3

Studying Metabolic Abnormalities in the Costello Syndrome HRAS G12V Mouse Model: Isolation of Mouse Embryonic Fibroblasts and Their In Vitro Adipocyte Differentiation.

Fidan M, Chennappan S, Cirstea IC. Fidan M, et al. Among authors: cirstea ic. Methods Mol Biol. 2021;2262:397-409. doi: 10.1007/978-1-0716-1190-6_24. Methods Mol Biol. 2021. PMID: 33977491

4

A novel in vitro assay to study chondrocyte-to-osteoblast transdifferentiation.

Tschaffon MEA, Reber SO, Schoppa A, Nandi S, Cirstea IC, Aszodi A, Ignatius A, Haffner-Luntzer M. Tschaffon MEA, et al. Among authors: cirstea ic. Endocrine. 2022 Jan;75(1):266-275. doi: 10.1007/s12020-021-02853-4. Epub 2021 Sep 16. Endocrine. 2022. PMID: 34529238 Free PMC article.

5

The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth.

Caratti B, Fidan M, Caratti G, Breitenecker K, Engler M, Kazemitash N, Traut R, Wittig R, Casanova E, Ahmadian MR, Tuckermann JP, Moll HP, Cirstea IC. Caratti B, et al. Among authors: cirstea ic. Sci Signal. 2022 Mar 22;15(726):eabm4452. doi: 10.1126/scisignal.abm4452. Epub 2022 Mar 22. Sci Signal. 2022. PMID: 35316097

6

Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing.

Ahmad M, Krüger BT, Kroll T, Vettorazzi S, Dorn AK, Mengele F, Lee S, Nandi S, Yilmaz D, Stolz M, Tangudu NK, Vázquez DC, Pachmayr J, Cirstea IC, Spasic MV, Ploubidou A, Ignatius A, Tuckermann J. Ahmad M, et al. Among authors: cirstea ic. Bone Res. 2022 Apr 6;10(1):33. doi: 10.1038/s41413-022-00195-z. Bone Res. 2022. PMID: 35383146 Free PMC article.

7

Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model.

Nandi S, Chennappan S, Andrasch Y, Fidan M, Engler M, Ahmad M, Tuckermann JP, Zenker M, Cirstea IC. Nandi S, et al. Among authors: cirstea ic. Front Cell Dev Biol. 2022 Oct 18;10:1000575. doi: 10.3389/fcell.2022.1000575. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36330334 Free PMC article.

8

ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection.

Engler M, Albers D, Von Maltitz P, Groß R, Münch J, Cirstea IC. Engler M, et al. Among authors: cirstea ic. Life Sci Alliance. 2023 Jul 4;6(9):e202201880. doi: 10.26508/lsa.202201880. Print 2023 Sep. Life Sci Alliance. 2023. PMID: 37402592 Free PMC article.

9

A restricted spectrum of NRAS mutations causes Noonan syndrome.

Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M. Cirstea IC, et al. Nat Genet. 2010 Jan;42(1):27-9. doi: 10.1038/ng.497. Epub 2009 Dec 6. Nat Genet. 2010. PMID: 19966803 Free PMC article.

10

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes.

Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR. Cirstea IC, et al. Hum Mol Genet. 2013 Jan 15;22(2):262-70. doi: 10.1093/hmg/dds426. Epub 2012 Oct 11. Hum Mol Genet. 2013. PMID: 23059812

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