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Computational Approaches for the Discovery of GPER Targeting Compounds.
Grande F, Occhiuzzi MA, Lappano R, Cirillo F, Guzzi R, Garofalo A, Jacquot Y, Maggiolini M, Rizzuti B. Grande F, et al. Among authors: cirillo f. Front Endocrinol (Lausanne). 2020 Aug 4;11:517. doi: 10.3389/fendo.2020.00517. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32849301 Free PMC article. Review.
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
Santolla MF, Avino S, Pellegrino M, De Francesco EM, De Marco P, Lappano R, Vivacqua A, Cirillo F, Rigiracciolo DC, Scarpelli A, Abonante S, Maggiolini M. Santolla MF, et al. Among authors: cirillo f. Cell Death Dis. 2015 Jul 30;6(7):e1834. doi: 10.1038/cddis.2015.201. Cell Death Dis. 2015. PMID: 26225773 Free PMC article.
Copper activates HIF-1α/GPER/VEGF signalling in cancer cells.
Rigiracciolo DC, Scarpelli A, Lappano R, Pisano A, Santolla MF, De Marco P, Cirillo F, Cappello AR, Dolce V, Belfiore A, Maggiolini M, De Francesco EM. Rigiracciolo DC, et al. Among authors: cirillo f. Oncotarget. 2015 Oct 27;6(33):34158-77. doi: 10.18632/oncotarget.5779. Oncotarget. 2015. PMID: 26415222 Free PMC article.
Protective Role of GPER Agonist G-1 on Cardiotoxicity Induced by Doxorubicin.
De Francesco EM, Rocca C, Scavello F, Amelio D, Pasqua T, Rigiracciolo DC, Scarpelli A, Avino S, Cirillo F, Amodio N, Cerra MC, Maggiolini M, Angelone T. De Francesco EM, et al. Among authors: cirillo f. J Cell Physiol. 2017 Jul;232(7):1640-1649. doi: 10.1002/jcp.25585. Epub 2017 Feb 16. J Cell Physiol. 2017. PMID: 27607345
The lauric acid-activated signaling prompts apoptosis in cancer cells.
Lappano R, Sebastiani A, Cirillo F, Rigiracciolo DC, Galli GR, Curcio R, Malaguarnera R, Belfiore A, Cappello AR, Maggiolini M. Lappano R, et al. Among authors: cirillo f. Cell Death Discov. 2017 Sep 18;3:17063. doi: 10.1038/cddiscovery.2017.63. eCollection 2017. Cell Death Discov. 2017. PMID: 28924490 Free PMC article.
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
Cirillo F, Pellegrino M, Malivindi R, Rago V, Avino S, Muto L, Dolce V, Vivacqua A, Rigiracciolo DC, De Marco P, Sebastiani A, Abonante S, Nakajima M, Lappano R, Maggiolini M. Cirillo F, et al. Oncotarget. 2017 Nov 20;8(63):106608-106624. doi: 10.18632/oncotarget.22541. eCollection 2017 Dec 5. Oncotarget. 2017. PMID: 29290975 Free PMC article.
254 results