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T cell receptor (TCR) gene transfer with lentiviral vectors allows efficient redirection of tumor specificity in naive and memory T cells without prior stimulation of endogenous TCR.
Circosta P, Granziero L, Follenzi A, Vigna E, Stella S, Vallario A, Elia AR, Gammaitoni L, Vitaggio K, Orso F, Geuna M, Sangiolo D, Todorovic M, Giachino C, Cignetti A. Circosta P, et al. Hum Gene Ther. 2009 Dec;20(12):1576-88. doi: 10.1089/hum.2009.117. Hum Gene Ther. 2009. PMID: 19678763
TCR transfer induces TCR-mediated tonic inhibition of RAG genes in human T cells.
Orlando L, Accomasso L, Circosta P, Turinetto V, Lantelme E, Porcedda P, Minieri V, Pautasso M, Willemsen RA, Cignetti A, Giachino C. Orlando L, et al. Among authors: circosta p. Mol Immunol. 2011 Jul;48(12-13):1369-76. doi: 10.1016/j.molimm.2011.02.015. Epub 2011 Apr 8. Mol Immunol. 2011. PMID: 21481940
Cytokine-induced killer cells engineered with exogenous T-cell receptors directed against melanoma antigens: enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition.
Elia AR, Circosta P, Sangiolo D, Bonini C, Gammaitoni L, Mastaglio S, Genovese P, Geuna M, Avolio F, Inghirami G, Tarella C, Cignetti A. Elia AR, et al. Among authors: circosta p. Hum Gene Ther. 2015 Apr;26(4):220-31. doi: 10.1089/hum.2014.112. Epub 2015 Apr 13. Hum Gene Ther. 2015. PMID: 25758764
38 results