Cioffi CL - Search Results

1

Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2.

Gallagher CI, Frangos ZJ, Sheipouri D, Shimmon S, Duman MN, Jayakumar S, Cioffi CL, Rawling T, Vandenberg RJ. Gallagher CI, et al. Among authors: cioffi cl. ACS Chem Neurosci. 2023 Aug 2;14(15):2634-2647. doi: 10.1021/acschemneuro.3c00167. Epub 2023 Jul 19. ACS Chem Neurosci. 2023. PMID: 37466545

2

[No title available]

[No authors listed] [No authors listed] PMID: 36783988

3

Bafna K, Cioffi CL, Krug RM, Montelione GT. Bafna K, et al. Among authors: cioffi cl. Front Chem. 2022 Oct 6;10:948553. doi: 10.3389/fchem.2022.948553. eCollection 2022. Front Chem. 2022. PMID: 36353143 Free PMC article.

4

The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites.

Chater RC, Quinn AS, Wilson K, Frangos ZJ, Sutton P, Jayakumar S, Cioffi CL, O'Mara ML, Vandenberg RJ. Chater RC, et al. Among authors: cioffi cl. J Neurochem. 2023 Dec 22. doi: 10.1111/jnc.16028. Online ahead of print. J Neurochem. 2023. PMID: 38131125

5

The novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration.

Wang Y, Ma X, Muthuraman P, Raja A, Jayaraman A, Petrukhin K, Cioffi CL, Ma JX, Moiseyev G. Wang Y, et al. Among authors: cioffi cl. PLoS One. 2022 Oct 13;17(10):e0269437. doi: 10.1371/journal.pone.0269437. eCollection 2022. PLoS One. 2022. PMID: 36227868 Free PMC article.

6

Inhibition of Glycine Re-Uptake: A Potential Approach for Treating Pain by Augmenting Glycine-Mediated Spinal Neurotransmission and Blunting Central Nociceptive Signaling.

Cioffi CL. Cioffi CL. Biomolecules. 2021 Jun 10;11(6):864. doi: 10.3390/biom11060864. Biomolecules. 2021. PMID: 34200954 Free PMC article. Review.

7

Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.

Cioffi CL, Raja A, Muthuraman P, Jayaraman A, Jayakumar S, Varadi A, Racz B, Petrukhin K. Cioffi CL, et al. J Med Chem. 2021 Jul 8;64(13):9010-9041. doi: 10.1021/acs.jmedchem.1c00099. Epub 2021 Jun 17. J Med Chem. 2021. PMID: 34138572 Free PMC article.

8

Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.

Cioffi CL, Muthuraman P, Raja A, Varadi A, Racz B, Petrukhin K. Cioffi CL, et al. J Med Chem. 2020 Oct 8;63(19):11054-11084. doi: 10.1021/acs.jmedchem.0c00996. Epub 2020 Sep 17. J Med Chem. 2020. PMID: 32878437 Free PMC article.

9

Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2.

Mostyn SN, Sarker S, Muthuraman P, Raja A, Shimmon S, Rawling T, Cioffi CL, Vandenberg RJ. Mostyn SN, et al. Among authors: cioffi cl. ACS Chem Neurosci. 2020 May 6;11(9):1250-1258. doi: 10.1021/acschemneuro.9b00655. Epub 2020 Apr 9. ACS Chem Neurosci. 2020. PMID: 32191428 Free PMC article.

10

Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis.

Ma Z, King K, Alqahtani M, Worden M, Muthuraman P, Cioffi CL, Bakshi CS, Malik M. Ma Z, et al. Among authors: cioffi cl. PLoS One. 2019 Oct 24;14(10):e0224094. doi: 10.1371/journal.pone.0224094. eCollection 2019. PLoS One. 2019. PMID: 31648246 Free PMC article.

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